Catechols

Known as: o Dihydroxybenzenes, ortho Dihydroxybenzenes, o-Dihydroxybenzenes 
A group of 1,2-benzenediols that contain the general formula R-C6H5O2.
National Institutes of Health

Related topics

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49 relations

Narrower (45)

2,3-dihydroxybenzaldehyde2,3-dihydroxybiphenyl2,4-dichlorophenoxypropionic acid3,4,5-trichlorocatechol
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In Bloodagonistsantagonists & inhibitorschemical synthesis

Papers overview

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Highly Cited
2010
Highly Cited
2010
Iron Traffics in Circulation Bound to a Siderocalin (Ngal)-Catechol Complex
The lipocalins are secreted proteins that bind small organic molecules. Scn-Ngal (also known as neutrophil gelatinase associated… (More)
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Highly Cited
2006
Highly Cited
2006
Inhibition of DNA methylation by caffeic acid and chlorogenic acid, two common catechol-containing coffee polyphenols.
We studied the modulating effects of caffeic acid and chlorogenic acid (two common coffee polyphenols) on the in vitro… (More)
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Highly Cited
2006
Highly Cited
2006
Cytosolic catechols inhibit alpha-synuclein aggregation and facilitate the formation of intracellular soluble oligomeric intermediates.
Aberrant aggregation of alpha-synuclein (alpha-syn) to form fibrils and insoluble aggregates has been implicated in the… (More)
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Review
2003
Review
2003
Sources and significance of plasma levels of catechols and their metabolites in humans.
Human plasma contains several catechols, including the catecholamines norepinephrine, epinephrine, and dopamine, their precursor… (More)
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Highly Cited
2002
Highly Cited
2002
Inhibition of NADPH oxidase activation in endothelial cells by ortho-methoxy-substituted catechols.
NADPH oxidase is a major enzymatic source of oxygen free radicals in stimulated endothelial cells (ECs). The ortho-methoxy… (More)
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Highly Cited
2000
Highly Cited
2000
Induction of uterine adenocarcinoma in CD-1 mice by catechol estrogens.
Catechol estrogens may mediate estrogen-induced carcinogenesis because 4-hydroxyestradiol induces DNA damage and renal tumors in… (More)
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Highly Cited
1999
Highly Cited
1999
Characterization and implications of estrogenic down-regulation of human catechol-O-methyltransferase gene transcription.
Catechol-O-methyltransferase (COMT, EC 2.1.1.6) is a ubiquitous enzyme that is crucial to the metabolism of carcinogenic… (More)
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Highly Cited
1998
Highly Cited
1998
Genetic polymorphisms in catechol-O-methyltransferase, menopausal status, and breast cancer risk.
Polymorphic catechol-O-methyltransferase (COMT) catalyzes the O-methylation of estrogen catechols. In a case-control study, we… (More)
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Highly Cited
1973
Highly Cited
1973
Iron-binding catechols and virulence in Escherichia coli.
A comparison of viral-induced unresponsiveness of phytohemagglutinin (PHA)-induced deoxyribonucleic acid (DNA) synthesis of mouse… (More)
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Highly Cited
1958
Highly Cited
1958
Enzymatic O-methylation of epinephrine and other catechols.
Many studies in vitro have implicated cytochrome oxidase and monoamine oxidase in the metabolism of epinephrine and other… (More)
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