• Publications
  • Influence
Flavonoids as antioxidants: determination of radical-scavenging efficiencies.
TLDR
The radical chemistry of flavonoids not only is of interest from a kinetic or mechanistic point of view but also offers considerable insight into structural relationships of highly evolved plant components. Expand
Inhibition of the bleaching of the carotenoid crocin a rapid test for quantifying antioxidant activity
Abstract The carotenoids crocin and canthaxanthin were bleached by photolytically produced alkoxyl radicals derived from either tert-butyl hydroperoxide or fatty acid hydroperoxides. The inhibitionExpand
Assaying for hydroxyl radicals: hydroxylated terephthalate is a superior fluorescence marker than hydroxylated benzoate.
TLDR
The assay can be used to detect 'free' *OH radicals produced by the radiolysis of water as well as 'hydroxyl analogous species' that have been suggested to arise from the interaction of complex-bound reduced metal with either oxygen or hydrogen peroxide, e.g. from Fenton reactions. Expand
Radical chemistry of flavonoid antioxidants.
TLDR
Flavonoid aglycones, members of an ubiquitous class of plant phenols, have often been proposed to act as antioxidants, but only qualitative conclusions could be drawn. Expand
To what end does nature produce superoxide? NADPH oxidase as an autocrine modifier of membrane phospholipids generating paracrine lipid messengers.
  • M. Saran
  • Chemistry, Medicine
  • Free radical research
  • 1 October 2003
TLDR
An overall picture is presented that suggests that O2*-/HO2* radicals, by modifying cell membranes, help other agents gain access to the hydrophobic region of phospholipid bilayers and hence contribute to lipid-dependent signaling cascades and the potential evolution of the "radical theory of ageing" to a "lipid theory of aging". Expand
Radical scavenging by flavonoid antioxidants.
  • W. Bors, M. Saran
  • Chemistry, Medicine
  • Free radical research communications
  • 1987
TLDR
The data do not conclusively prove that the biological function of flavonoids might be the scavenging of radicals, but the very high rate constants of formation and the relative stability of some of the aroxyl radicals, are in support of such a hypothesis. Expand
On the nature of biochemically generated hydroxyl radicals. Studies using the bleaching of p-nitrosodimethylaniline as a direct assay method.
TLDR
It is concluded that, under biochemical conditions as opposed to radiolysis or photolysis, no freely diffusable OH radicals are formed. Expand
Flavonoid antioxidants: rate constants for reactions with oxygen radicals.
TLDR
This chapter describes the flavonoids that are plant secondary metabolites having a polyphenol structure, occurring mostly as glycosides or methoxylated derivatives, and sometimes as aglycones, and discusses the methods for oxygen radical generation. Expand
DETECTION OF OXYGEN RADICALS IN BIOLOGICAL REACTIONS
TLDR
The systems discussed include the autoxidation of adrenalin to adrenochrome, the oxidation of hydroxylamine to nitrite, the generation of ethylene from methional, and the scavenging of OH radicals by p‐nitroso‐dimethylaniline. Expand
Oxygen radicals acting as chemical messengers: a hypothesis.
  • M. Saran, W. Bors
  • Chemistry, Medicine
  • Free radical research communications
  • 1989
Based on a critical reappraisal of the reactions of radicals in a biological milieu, a hypothesis is proposed according to which superoxide anion radicals act as biological messengers rather than asExpand
...
1
2
3
4
5
...