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monastrol

 
National Institutes of Health

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Highly Cited
2011
Highly Cited
2011
A general, efficient and green method for the synthesis of dihydropyrimidinones is described under mild conditions employing low… Expand
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Highly Cited
2006
Highly Cited
2006
The synthesis and differential antiproliferative activity of monastrol (1a), oxo-monastrol (1b) and eight oxygenated derivatives… Expand
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Highly Cited
2005
Highly Cited
2005
Monastrol is a small, cell-permeable molecule that arrests cells in mitosis by specifically inhibiting Eg5, a member of the… Expand
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Highly Cited
2004
Highly Cited
2004
BACKGROUND The stable association of chromosomes with both poles of the mitotic spindle (biorientation) depends on spindle… Expand
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Highly Cited
2003
Highly Cited
2003
The proper segregation of sister chromatids in mitosis depends on bipolar attachment of all chromosomes to the mitotic spindle… Expand
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Highly Cited
2003
Highly Cited
2003
The microtubule-dependent kinesin-like protein Eg5 from Homo sapiens is involved in the assembly of the mitotic spindle. It shows… Expand
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Highly Cited
2002
Highly Cited
2002
Monastrol, a cell-permeable inhibitor of the kinesin Eg5, has been used to probe the dynamic organization of the mitotic spindle… Expand
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Highly Cited
2002
Highly Cited
2002
We screened a small-molecule library for inhibitors of rabbit muscle myosin II subfragment 1 (S1) actin-stimulated ATPase… Expand
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Highly Cited
2000
Highly Cited
2000
Monastrol, a cell-permeable small molecule inhibitor of the mitotic kinesin, Eg5, arrests cells in mitosis with monoastral… Expand
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Highly Cited
1999
Highly Cited
1999
Small molecules that perturb specific protein functions are valuable tools for dissecting complex processes in mammalian cells. A… Expand
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