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monastrol

National Institutes of Health

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PyrimidinesThiones

Papers overview

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2014
2014
A monastrol-derived compound, LaSOM 63, inhibits ecto-5'nucleotidase/CD73 activity and induces apoptotic cell death of glioma cell lines.
BACKGROUND/AIM Glioblastoma multiforme is the most malignant type of glioma. Ecto-5'-nucleotidase (ecto-5'NT), a glioma… 
2009
2009
Zeolite catalyzed solvent-free one-pot synthesis of dihydropyrimidin-2(1H)-ones – A practical synthesis of monastrol
A zeolite-catalyzed, simple, one-pot, solvent-free, cost effective, and environmentally benign process for the synthesis of… 
2008
2008
Crystal structure of HsEg5 in complex with clinical candidate CK0238273 provides insight into inhibitory mechanism, potency, and specificity.
2007
2007
Rapid preparation of the mitotic kinesin Eg5 inhibitor monastrol using controlled microwave-assisted synthesis
We present here a protocol for the synthesis of the dihydropyrimidine (DHPM) derivative monastrol, which is known to be a… 
Highly Cited
2006
Highly Cited
2006
A structural model for monastrol inhibition of dimeric kinesin Eg5
Eg5 or KSP is a homotetrameric Kinesin‐5 involved in centrosome separation and assembly of the bipolar mitotic spindle… 
Highly Cited
2006
Highly Cited
2006
A Pathway of Structural Changes Produced by Monastrol Binding to Eg5*
Monastrol is a small molecule inhibitor that is specific for Eg5, a member of the kinesin 5 family of mitotic motors… 
Highly Cited
2006
Highly Cited
2006
Allosteric inhibition of kinesin-5 modulates its processive directional motility
Small-molecule inhibitors of kinesin-5 (refs. 1–3), a protein essential for eukaryotic cell division4, represent alternatives to… 
Highly Cited
2006
Highly Cited
2006
Induction of apoptosis by monastrol, an inhibitor of the mitotic kinesin Eg5, is independent of the spindle checkpoint
Spindle poisons such as paclitaxel are widely used as cancer therapeutics. By interfering with microtubule dynamics, paclitaxel… 
2005
2005
New protocol for Biginelli reaction-a practical synthesis of Monastrol
A simple, efficient, and cost-effective method has been developed for the synthesis of 3,4- dihydropyrimidin-2(1H)-ones by a one… 
2004
2004
Mechanism of inhibition of human KSP by monastrol: insights from kinetic analysis and the effect of ionic strength on KSP inhibition.
Kinesin motor proteins utilize the energy from ATP hydrolysis to transport cellular cargo along microtubules. Kinesins that play… 
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