monastrol
National Institutes of Health
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A general, efficient and green method for the synthesis of dihydropyrimidinones is described under mild conditions employing low…
Human Eg5, responsible for the formation of the bipolar mitotic spindle, has been identified recently as one of the targets of S…
Eg5 or KSP is a homotetrameric Kinesin‐5 involved in centrosome separation and assembly of the bipolar mitotic spindle…
Background A recent crystal structure of monastrol in a ternary complex with the kinesin Eg5 motor domain highlights a novel…
We screened a small-molecule library for inhibitors of rabbit muscle myosin II subfragment 1 (S1) actin-stimulated ATPase…