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The bipolar mitotic kinesin Eg5 moves on both microtubules that it crosslinks
During cell division, mitotic spindles are assembled by microtubule-based motor proteins. The bipolar organization of spindles is essential for proper segregation of chromosomes, and requiresExpand
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Dynamic Microtubules Regulate Dendritic Spine Morphology and Synaptic Plasticity
Dendritic spines are the major sites of excitatory synaptic input, and their morphological changes have been linked to learning and memory processes. Here, we report that growing microtubule plusExpand
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Microtubule Stabilization Reduces Scarring and Causes Axon Regeneration After Spinal Cord Injury
Taxol stimulates the capacity of axons to grow after spinal cord injury. Hypertrophic scarring and poor intrinsic axon growth capacity constitute major obstacles for spinal cord repair. TheseExpand
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TRAK/Milton Motor-Adaptor Proteins Steer Mitochondrial Trafficking to Axons and Dendrites
In neurons, the distinct molecular composition of axons and dendrites is established through polarized targeting mechanisms, but it is currently unclear how nonpolarized cargoes, such asExpand
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Axon Extension Occurs Independently of Centrosomal Microtubule Nucleation
Centrosome-Free Axonal Regeneration Neuronal axon growth is thought to depend on microtubules that are assembled at the centrosome, the classical microtubule organizing center (MTOC), which may evenExpand
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Pericentrosomal targeting of Rab6 secretory vesicles by Bicaudal-D-related protein 1 (BICDR-1) regulates neuritogenesis
Membrane and secretory trafficking are essential for proper neuronal development. However, the molecular mechanisms that organize secretory trafficking are poorly understood. Here, we identifyExpand
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Mixed Microtubules Steer Dynein-Driven Cargo Transport into Dendrites
BACKGROUND To establish and maintain their polarized morphology, neurons employ active transport driven by molecular motors to sort cargo between axons and dendrites. However, the basic traffic rulesExpand
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Microtubule cross-linking triggers the directional motility of kinesin-5
Although assembly of the mitotic spindle is known to be a precisely controlled process, regulation of the key motor proteins involved remains poorly understood. In eukaryotes, homotetramericExpand
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Building the Neuronal Microtubule Cytoskeleton
Microtubules are one of the major cytoskeletal components of neurons, essential for many fundamental cellular and developmental processes, such as neuronal migration, polarity, and differentiation.Expand
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Allosteric inhibition of kinesin-5 modulates its processive directional motility
Small-molecule inhibitors of kinesin-5 (refs. 1–3), a protein essential for eukaryotic cell division4, represent alternatives to antimitotic agents that target tubulin5,6. While tubulin is needed forExpand
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