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The kinetic mechanism of myosin V.
TLDR
Myosin V is tuned for processive movement on actin and will be capable of transporting cargo at lower motor densities than any other characterized myosin, in that ADP release is the rate-limiting step for the actin-activated ATPase cycle. Expand
The role of myosin II in glioma invasion of the brain.
TLDR
The results demonstrate that the A and B isoforms of myosin II are specifically required when a glioma cell has to squeeze through pores smaller than its nuclear diameter, and support a model in which the neural progenitor-like mode of gliomas invasion and the requirement for myosIn II represent an adaptation needed to move within the brain, which has a submicrometer effective pore size. Expand
Kinetic Tuning of Myosin via a Flexible Loop Adjacent to the Nucleotide Binding Pocket*
TLDR
Through a combination of solute quenching and transient fluorescence measurements, it is concluded that, as the loop gets smaller, access to the nucleotide pocket is more restricted, ATP binding becomes less favored, and ADP binding becomes more favored and the rate of ATP hydrolysis is slowed. Expand
Phase I and correlative biology study of cilengitide in patients with recurrent malignant glioma.
TLDR
Cilengitide is well tolerated to doses of 2,400 mg/m2, durable complete and partial responses were seen in this phase I study, and clinical response appears related to rCBF changes. Expand
Glioblastoma Models Reveal the Connection between Adult Glial Progenitors and the Proneural Phenotype
TLDR
Insight is offered into the relationship between adult glial progenitors and Proneural GBM, and molecular alterations that lead to more aggressive tumor growth are identified. Expand
A Model of Myosin V Processivity*
TLDR
Interestingly, both heads release phosphate rapidly upon the initial encounter with an actin filament, suggesting that there is little or no intramolecular strain associated with this step, and under steady-state conditions it is essentially prevented in the lead head until the rear head detaches. Expand
Determinants of maximal force transmission in a motor-clutch model of cell traction in a compliant microenvironment.
TLDR
It is found that the optimal stiffness is generally more sensitive to clutch parameters than to motor parameters, but that single parameter changes are generally only effective over a small range of values, and that dual parameter changes offer a larger dynamic range for tuning the optimum. Expand
A phase I open-label, dose-escalation, multi-institutional trial of injection with an E1B-Attenuated adenovirus, ONYX-015, into the peritumoral region of recurrent malignant gliomas, in the adjuvant
TLDR
Injection of ONYX-015 into glioma cavities is well tolerated at doses up to 10(10) pfu, and in patients who underwent a second resection 3 months after ONYx-015 injection, a lymphocytic and plasmacytoid cell infiltrate was observed. Expand
The Structural Basis of Force Generation by the Mitotic Motor Kinesin-5*
TLDR
The structures indicate that allosteric inhibitors of human kinesin-5, which are being developed as anti-cancer therapeutics, bind to a motor conformation that occurs in the course of normal function, however, due to evolutionarily defined sequence variations in L5, this conformation is not adopted by invertebrate kinesIn-5s, explaining their resistance to drug inhibition. Expand
Myosin IIB Is Unconventionally Conventional*
TLDR
It is demonstrated that myosin IIB, a cytoplasmic myos in II particularly enriched in the central nervous system and cardiac tissue, has a number of features that it shares instead with “unconventional” myosIn isoforms, including myosins V and VI, including a high duty ratio, rate-limiting ADP release, and high ADP affinity. Expand
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