T. Kapoor

Publications190
h-index55
Citations11,696
Highly Influential Citations740
Claim Author Page
Author pages are created from data sourced from our academic publisher partnerships and public sources.

Recommended Authors

  • T. Mitchison
  • 412 Publications, 55,694 Citations
  • E. Salmon
  • 212 Publications, 25,592 Citations
  • R. Vale
  • 272 Publications, 36,189 Citations
  • A. Hyman
  • 353 Publications, 38,638 Citations
  • Publications
  • Influence
Probing Spindle Assembly Mechanisms with Monastrol, a Small Molecule Inhibitor of the Mitotic Kinesin, Eg5
Monastrol, a cell-permeable small molecule inhibitor of the mitotic kinesin, Eg5, arrests cells in mitosis with monoastral spindles. Here, we use monastrol to probe mitotic mechanisms. We find that… Expand
  • 640
  • 43
  • PDF
The bipolar mitotic kinesin Eg5 moves on both microtubules that it crosslinks
During cell division, mitotic spindles are assembled by microtubule-based motor proteins. The bipolar organization of spindles is essential for proper segregation of chromosomes, and requires… Expand
  • 569
  • 42
  • PDF
Microtubule attachment and spindle assembly checkpoint signalling at the kinetochore
In eukaryotes, chromosome segregation during cell division is facilitated by the kinetochore, a multiprotein structure that is assembled on centromeric DNA. The kinetochore attaches chromosomes to… Expand
  • 479
  • 37
Formation of stable attachments between kinetochores and microtubules depends on the B56-PP2A phosphatase
Error-free chromosome segregation depends on the precise regulation of phosphorylation to stabilize kinetochore–microtubule attachments (K-fibres) on sister chromatids that have attached to opposite… Expand
  • 227
  • 30
Chromosomes Can Congress to the Metaphase Plate Before Biorientation
The stable propagation of genetic material during cell division depends on the congression of chromosomes to the spindle equator before the cell initiates anaphase. It is generally assumed that… Expand
  • 399
  • 27
  • PDF
The Kinesin-4 Protein KIF7 Regulates Mammalian Hedgehog Signaling by Organizing the Cilia Tip Compartment
Mammalian Hedgehog (Hh) signal transduction requires a primary cilium, a microtubule-based organelle, and the Gli–Sufu complexes that mediate Hh signalling, which are enriched at cilia tips. Kif7, a… Expand
  • 199
  • 27
Correcting improper chromosome–spindle attachments during cell division
For accurate segregation of chromosomes during cell division, microtubule fibres must attach sister kinetochores to opposite poles of the mitotic spindle (bi-orientation). Aurora kinases are linked… Expand
  • 435
  • 26
  • PDF
Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen.
Small molecules that perturb specific protein functions are valuable tools for dissecting complex processes in mammalian cells. A combination of two phenotype-based screens, one based on a specific… Expand
  • 1,092
  • 23
  • PDF
Constitutive Mad1 targeting to kinetochores uncouples checkpoint signalling from chromosome biorientation
Accurate chromosome segregation depends on biorientation, whereby sister chromatids attach to microtubules from opposite spindle poles. The spindle-assembly checkpoint is a surveillance mechanism in… Expand
  • 174
  • 22
Insights into Antiparallel Microtubule Crosslinking by PRC1, a Conserved Nonmotor Microtubule Binding Protein
Formation of microtubule architectures, required for cell shape maintenance in yeast, directional cell expansion in plants and cytokinesis in eukaryotes, depends on antiparallel microtubule… Expand
  • 226
  • 21