microsatellite instability diagnostic test

Known as: Microsatellite instability, instability microsatellite 
 
National Institutes of Health

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Topic mentions per year

1993-2017
05010015019932017

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Highly Cited
2012
Highly Cited
2012
To characterize somatic alterations in colorectal carcinoma, we conducted a genome-scale analysis of 276 samples, analysing exome… (More)
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Highly Cited
2006
Highly Cited
2006
BACKGROUND & AIMS Sporadic colorectal cancers with a high degree of microsatellite instability are a clinically distinct subgroup… (More)
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Highly Cited
2005
Highly Cited
2005
BACKGROUND Germ-line mutations in the mismatch-repair genes MLH1, MSH2, MSH6, and PMS2 lead to the development of the Lynch… (More)
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Highly Cited
2003
Highly Cited
2003
BACKGROUND Colon cancers with high-frequency microsatellite instability have clinical and pathological features that distinguish… (More)
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Highly Cited
2002
Highly Cited
2002
BACKGROUND & AIMS The microsatellite instability (MSI) phenotype is a characteristic of the hereditary nonpolyposis colorectal… (More)
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Highly Cited
2001
Highly Cited
2001
A BSTRACT Background Adjuvant chemotherapy improves survival among patients with stage III colon cancer, but no reliable… (More)
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Highly Cited
2000
Highly Cited
2000
BACKGROUND Colorectal cancer can arise through two distinct mutational pathways: microsatellite instability or chromosomal… (More)
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Highly Cited
1998
Highly Cited
1998
Loss of imprinting (LOI) is an epigenetic alteration of some cancers involving loss of parental origin-specific expression of… (More)
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Highly Cited
1996
Highly Cited
1996
To date, at least four genes involved in DNA mismatch repair, hMSH2, hMLH1, hPMS1 and hPMS2, have been demonstrated to be altered… (More)
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Highly Cited
1995
Highly Cited
1995
The TGF beta type II receptor (RII) was found to be mutated within a polyadenine tract in 100 of 111 (90%) colorectal cancers… (More)
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