microsatellite instability diagnostic test

To characterize somatic alterations in colorectal carcinoma, we conducted a genome-scale analysis of 276 samples, analysing exome… (More)

BACKGROUND & AIMS Sporadic colorectal cancers with a high degree of microsatellite instability are a clinically distinct subgroup… (More)

BACKGROUND Germ-line mutations in the mismatch-repair genes MLH1, MSH2, MSH6, and PMS2 lead to the development of the Lynch… (More)

BACKGROUND Colon cancers with high-frequency microsatellite instability have clinical and pathological features that distinguish… (More)

BACKGROUND & AIMS The microsatellite instability (MSI) phenotype is a characteristic of the hereditary nonpolyposis colorectal… (More)

A BSTRACT Background Adjuvant chemotherapy improves survival among patients with stage III colon cancer, but no reliable… (More)

BACKGROUND Colorectal cancer can arise through two distinct mutational pathways: microsatellite instability or chromosomal… (More)

Loss of imprinting (LOI) is an epigenetic alteration of some cancers involving loss of parental origin-specific expression of… (More)

To date, at least four genes involved in DNA mismatch repair, hMSH2, hMLH1, hPMS1 and hPMS2, have been demonstrated to be altered… (More)

The TGF beta type II receptor (RII) was found to be mutated within a polyadenine tract in 100 of 111 (90%) colorectal cancers… (More)