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Stable fluorescent complexes of double-stranded DNA with bis-intercalating asymmetric cyanine dyes: properties and applications.
The synthesis, proof of structure, and the absorption and fluorescence properties of two new unsymmetrical cyanine dyes, thiazole orange dimer (TOTO; 1,1'-(4,4,7,7-tetramethyl-4,7-Expand
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Conical intersection dynamics of the primary photoisomerization event in vision
Ever since the conversion of the 11-cis retinal chromophore to its all-trans form in rhodopsin was identified as the primary photochemical event in vision, experimentalists and theoreticians haveExpand
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Mapping GFP structure evolution during proton transfer with femtosecond Raman spectroscopy
Tracing the transient atomic motions that lie at the heart of chemical reactions requires high-resolution multidimensional structural information on the timescale of molecular vibrations, whichExpand
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Development and multiplexed control of latching pneumatic valves using microfluidic logical structures.
Novel latching microfluidic valve structures are developed, characterized, and controlled independently using an on-chip pneumatic demultiplexer. These structures are based on pneumatic monolithicExpand
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Surface multiheme c-type cytochromes from Thermincola potens and implications for respiratory metal reduction by Gram-positive bacteria
Almost nothing is known about the mechanisms of dissimilatory metal reduction by Gram-positive bacteria, although they may be the dominant species in some environments. Thermincola potens strain JRExpand
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Retinal counterion switch in the photoactivation of the G protein-coupled receptor rhodopsin
The biological function of Glu-181 in the photoactivation process of rhodopsin is explored through spectroscopic studies of site-specific mutants. Preresonance Raman vibrational spectra of theExpand
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Ultra-high-speed DNA fragment separations using microfabricated capillary array electrophoresis chips.
  • A. Woolley, R. Mathies
  • Chemistry, Medicine
  • Proceedings of the National Academy of Sciences…
  • 22 November 1994
Capillary electrophoresis arrays have been fabricated on planar glass substrates by photolithographic masking and chemical etching techniques. The photolithographically defined channel patterns wereExpand
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Structural Observation of the Primary Isomerization in Vision with Femtosecond-Stimulated Raman
The primary event that initiates vision is the light-induced 11-cis to all-trans isomerization of retinal in the visual pigment rhodopsin. Despite decades of study with the traditional tools ofExpand
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Ultrafast excited-state isomerization in phytochrome revealed by femtosecond stimulated Raman spectroscopy
Photochemical interconversion between the red-absorbing (Pr) and the far-red-absorbing (Pfr) forms of the photosensory protein phytochrome initiates signal transduction in bacteria and higher plants.Expand
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