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Consistent rearrangement of chromosomal band 6p21 with generation of fusion genes JAZF1/PHF1 and EPC1/PHF1 in endometrial stromal sarcoma.
The PHF1 gene encodes a protein with two zinc finger motifs whose involvement in tumorigenesis and/or tumor progression has not been reported before, but its rearrangement clearly defines a new pathogenetic subgroup of ESS.
Cancer risk in humans predicted by increased levels of chromosomal aberrations in lymphocytes: Nordic study group on the health risk of chromosome damage.
An increased level of chromosome breakage appears to be a relevant biomarker of future cancer risk in peripheral blood lymphocytes, according to an ongoing Nordic cohort study of cancer incidence.
Prognostic impact of karyotypic findings in childhood acute lymphoblastic leukaemia: a Nordic series comparing two treatment periods
The prognostic impact of acquired chromosome abnormalities was evaluated in a population‐based consecutive series of 768 children with acute lymphoblastic leukaemia (ALL) and only WBC and modal chromosome number were shown to be significant independent risk factors.
Uterine leiomyoma cytogenetics
Karyotypic similarities exist also between leiomyoma and pleomorphic adenoma of the salivary gland, which includes a subset of tumors with anomalies of 12q13‐15, and with myxoid liposarcoma, which has t(12;16)(q13;p11) as a tumor‐specific rearrangement.
Cytogenetic findings in primary and secondary MDS.
- S. Heim
- MedicineLeukemia research
Identification of cytogenetic subgroups and karyotypic pathways in transitional cell carcinoma.
- M. Höglund, T. Säll, S. Heim, F. Mitelman, N. Mandahl, I. Fadl-Elmula
- MedicineCancer research
- 15 November 2001
It is suggested that progression involves the acquisition of cytogenetically detectable and submicroscopic genetic changes at comparable frequencies and that the imbalances -9, +7, and 1q+ appear earlier than expected from random events and -6q, -5Q, -18, +5p, -22p, and -15 appear later than expected.
Cytogenetic clues to breast carcinogenesis
A multipathway model of mammary carcinogenesis is proposed that takes into consideration the genetic heterogeneity revealed by the karyotypic findings and the possible clinical applications of the cytogenetic knowledge are reviewed.
Cytogenetic and molecular genetic analyses of endometrial stromal sarcoma: nonrandom involvement of chromosome arms 6p and 7p and confirmation of JAZF1/JJAZ1 gene fusion in t(7;17).
Assessment of clonal relationships in ipsilateral and bilateral multiple breast carcinomas by comparative genomic hybridisation and hierarchical clustering analysis
Comparison of genomic hybridisation analysis of 26 tumours from 12 breast cancer patients with multiple ipsilateral and/or bilateral carcinoma lesions concludes that CGH analysis of multiple breast carcinomas followed by unsupervised hierarchical clustering of the genomic imbalances is more reliable than previous criteria to determine the tumours’ clonal relationship in individual patients.
Karyotypic characterization of colorectal adenocarcinomas
- G. Bardi, T. Sukhikh, N. Pandis, C. Fenger, O. Kronborg, S. Heim
- MedicineGenes, chromosomes & cancer
- 1 February 1995
The cytogenetic data indicate that carcinomas located in the proximal colon and rectum, which often are near‐diploid with simple numerical changes and cytogenetically unrelated clones, probably arise through different mechanisms than do tumors located inThe distal colon, which more often have complex near‐triploid to near‐tetraploid karyotypes.