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A Human Genome Diversity Cell Line Panel
A resource of 1064 cultured lymphoblastoid cell lines (LCLs) ([1][1]) from individuals in different world populations and corresponding milligram quantities of DNA is deposited at the Foundation JeanExpand
A serine/threonine kinase gene defective in Peutz–Jeghers syndrome
The molecular background of the Peutz–Jeghers syndrome, a rare hereditary disease in which there is predisposition to benign and malignant tumours of many organ systems, is investigated and truncating germline mutations in a gene residing on chromosome 19p are identified. Expand
The ABC of APC.
Understanding to date of how mutations in the APC gene translate into changes at the protein level, which in turn contribute to the role of APC in tumorigenesis are dealt with. Expand
Common and rare variants in multifactorial susceptibility to common diseases
It is believed that this strategy can be successfully applied at present in order to unravel the contribution of rare variants to the multifactorial inheritance of common diseases, which could lead to the implementation of much needed preventative screening schemes. Expand
Production of monoclonal antibodies to group A erythrocytes, HLA and other human cell surface antigens-new tools for genetic analysis
The experiments established the usefulness of the bybrid myeloma technique in preparing monospecific antibodies against human cell surface antigens and highlights the possibilities not only of obtaining reagents for somatic cell genetics, but also of obtaining mouse antibodies detecting human antigenic polymorphisms. Expand
The Eurasian Heartland: A continental perspective on Y-chromosome diversity
This study reports the frequencies of 23 Y-chromosome biallelic polymorphism haplotypes in 1,935 men from 49 Eurasian populations, with a particular focus on Central Asia. Expand
Target genes of beta-catenin-T cell-factor/lymphoid-enhancer-factor signaling in human colorectal carcinomas.
  • B. Mann, M. Gelos, +8 authors C. Hanski
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 16 February 1999
Together with the other alterations, beta-catenin accumulation may contribute to the development and progression of colon carcinoma both by dedifferentiation and through proteolytic activity. Expand
APC mutations in sporadic colorectal tumors: A mutational "hotspot" and interdependence of the "two hits".
The results suggest that APC mutations occur in the great majority of colorectal cancers, the exceptions almost all being RER+ tumors, which may substitute for altered APC function by mutations in beta-catenin and/or at other loci. Expand
Use of a monoclonal antibody (W6/32) in structural studies of HLA-A,B,C, antigens.
The results suggest that the W6/32 antigenic determinant involves only amino acids of the HLA-A,B,C chain and is a product of their three dimensional configuration. Expand
Cancer stem cells from colorectal cancer-derived cell lines
It is shown that CD44+CD24+ cells enriched for colorectal CSCs in the HT29 and SW1222 cell lines, which can self-renew and reform all four CD44/CD24 subpopulations, are the most clonogenic in vitro and can initiate tumors in vivo. Expand