Igor L. Medintz

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Quantum dot bioconjugates for imaging, labelling and sensing.

Igor L. Medintz, H. Tetsuo Uyeda, E. R. Goldman, Hedi Mattoussi
Nature materials
2005

One of the fastest moving and most exciting interfaces of nanotechnology is the use of quantum dots (QDs) in biology. The unique optical properties of QDs make them appealing as in vivo and in vitro… (More)

Proteolytic activity monitored by fluorescence resonance energy transfer through quantum-dot-peptide conjugates.

Igor L. Medintz, Aaron R. Clapp, +6 authors Hedi Mattoussi
Nature materials
2006

Proteases are enzymes that catalyse the breaking of specific peptide bonds in proteins and polypeptides. They are heavily involved in many normal biological processes as well as in diseases,… (More)

Self-assembled nanoscale biosensors based on quantum dot FRET donors.

Igor L. Medintz, Aaron R. Clapp, Hedi Mattoussi, E. R. Goldman, Brent R. Fisher, J. Matthew Mauro
Nature materials
2003

The potential of luminescent semiconductor quantum dots (QDs) to enable development of hybrid inorganic-bioreceptor sensing materials has remained largely unrealized. We report the design, formation… (More)

Fluorescence resonance energy transfer between quantum dot donors and dye-labeled protein acceptors.

Aaron R. Clapp, Igor L. Medintz, J. Matthew Mauro, Brent R. Fisher, Moungi G Bawendi, Hedi Mattoussi
Journal of the American Chemical Society
2004

We used luminescent CdSe-ZnS core-shell quantum dots (QDs) as energy donors in fluorescent resonance energy transfer (FRET) assays. Engineered maltose binding protein (MBP) appended with an… (More)

Multiplexed toxin analysis using four colors of quantum dot fluororeagents.

E. R. Goldman, Aaron R. Clapp, +4 authors Hedi Mattoussi
Analytical chemistry
2004

Quantum dots (QDs) have the potential to simplify the performance of multiplexed analysis. In this work, we prepared bioinorganic conjugates made with highly luminescent semiconductor nanocrystals… (More)

Enhancing the stability and biological functionalities of quantum dots via compact multifunctional ligands.

Kimihiro Susumu, H. Tetsuo Uyeda, Igor L. Medintz, Thomas Pons, James B. Delehanty, Hedi Mattoussi
Journal of the American Chemical Society
2007

We have designed and synthesized a series of modular ligands based on poly(ethylene glycol) (PEG) coupled with functional terminal groups to promote water-solubility and biocompatibility of quantum… (More)

Functionalizing nanoparticles with biological molecules: developing chemistries that facilitate nanotechnology.

Kim E. Sapsford, W. Russ Algar, +5 authors Igor L. Medintz
Chemical reviews
2013

Chemistries that Facilitate Nanotechnology Kim E. Sapsford,† W. Russ Algar, Lorenzo Berti, Kelly Boeneman Gemmill,‡ Brendan J. Casey,† Eunkeu Oh, Michael H. Stewart, and Igor L. Medintz*,‡ †Division… (More)

Self-assembled quantum dot-peptide bioconjugates for selective intracellular delivery.

James B. Delehanty, Igor L. Medintz, Thomas Pons, Florence M. Brunel, Philip E. Dawson, Hedi Mattoussi
Bioconjugate chemistry
2006

We demonstrate the use of self-assembled luminescent semiconductor quantum dot (QD)-peptide bioconjugates for the selective intracellular labeling of several eukaryotic cell lines. A bifunctional… (More)

The controlled display of biomolecules on nanoparticles: a challenge suited to bioorthogonal chemistry.

W. Russ Algar, Duane E Prasuhn, +4 authors Igor L. Medintz
Bioconjugate chemistry
2011

Interest in developing diverse nanoparticle (NP)-biological composite materials continues to grow almost unabated. This is motivated primarily by the desire to simultaneously exploit the properties… (More)

Analyzing nanomaterial bioconjugates: a review of current and emerging purification and characterization techniques.

Kim E. Sapsford, Katherine M Tyner, Benita J. Dair, Jeffrey R. Deschamps, Igor L. Medintz
Analytical chemistry
2011

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