Skip to search formSkip to main contentSkip to account menu

metoprine

Known as: 2,4-diamino-5-(3',4'-dichlorophenyl)-6-methylpyrimidine, DDMP, methodichlorophen 
A diaminopyrimidine folate antagonist with potential antineoplastic activity. Metoprine inhibits dihydrofolate reductase, resulting in decreased… 
National Institutes of Health

Related topics

Related topics

6 relations

Broader (4)

Antineoplastic AgentsEnzyme InhibitorsFolic Acid AntagonistsPyrimethamine
NCIt Antineoplastic Agent Terminologyanalogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2011
2011
Evaluation of beer deterioration by gas chromatography-mass spectrometry/multivariate analysis: a rapid tool for assessing beer composition.
2011
2011
General food semiochemicals attract omnivorous German cockroaches, Blattella germanica.
Stale beer and peanut butter are effective baits for the German cockroach (GCRs), Blattella germanica (L.) (Dictyoptera… 
Highly Cited
2005
Highly Cited
2005
Use of a simplified HPLC-UV analysis for soyasaponin B determination: study of saponin and isoflavone variability in soybean cultivars and soy-based health food products.
Soyasaponins are phytochemicals of major interest for health. Their identification and quantification remain difficult owing to… 
2004
2004
Diagnostic value of different serological tests for tuberculosis in Poland.
The aim of the study was to test the diagnostic accuracy of several serological assays for the diagnosis of tuberculosis (TB) in… 
1996
1996
Prevention of Hydrogen Peroxide Damage by Soybean Saponins to Mouse Fibroblasts
H 
Highly Cited
1986
Highly Cited
1986
Is histamine an anticonvulsive inhibitory transmitter?
Highly Cited
1983
Highly Cited
1983
Patterns of cross-resistance to the antifolate drugs trimetrexate, metoprine, homofolate, and CB3717 in human lymphoma and osteosarcoma cells resistant to methotrexate.
Methotrexate (MTX)-resistant sublines of malignant human cells were selected in vitro by stepwise increase in drug concentration… 
Highly Cited
1982
Highly Cited
1982
Establishment of methotrexate-resistant human acute lymphoblastic leukemia cells in culture and effects of folate antagonists.
A human acute lymphoblastic T-cell line, MOLT-3, was fed with Roswell Park Memorial Institute Medium 1640-10% fetal bovine serum… 
1982
1982
Biochemical correlates of responsiveness and collateral sensitivity of some methotrexate-resistant murine tumors to the lipophilic antifolate, metoprine.
The M5076 murine "ovarian" tumor which is naturally refractive to methotrexate was found to be highly responsive to the… 
1975
1975
Methodichlorophen as anti-tumor drug.
Methodichlorophen was given to 26 patients with terminal malignant disease. Eight patients received adequate doses, and five of… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)