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metoprine
Known as:
2,4-diamino-5-(3',4'-dichlorophenyl)-6-methylpyrimidine
, DDMP
, methodichlorophen
A diaminopyrimidine folate antagonist with potential antineoplastic activity. Metoprine inhibits dihydrofolate reductase, resulting in decreased…
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National Institutes of Health
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Related topics
Related topics
6 relations
Broader (4)
Antineoplastic Agents
Enzyme Inhibitors
Folic Acid Antagonists
Pyrimethamine
NCIt Antineoplastic Agent Terminology
analogs & derivatives
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2011
2011
Isolation and Identification of an Antioxidant Substance from Heated Onion (Allium cepa L.)
I. Hwang
,
H. Kim
,
+6 authors
H. Jeong
2011
Corpus ID: 55602734
The objectives of this study were to identify antioxidant substance in heated onion. The isolation of active compound was…
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1987
1987
Inhibition of sound-induced convulsions by metoprine in the audiogenic seizure susceptible rat
L. Tuomisto
,
U. Tacke
,
A. Willman
Agents and Actions
1987
Corpus ID: 37373609
Metoprine which increases brain histamine by blocking its methylation, was recently demonstrated to inhibit electrically induced…
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1986
1986
Dissociation of thymidylate biosynthesis from DNA biosynthesis by 5-fluoro-2'-deoxyuridine and 5,8-dideazaisofolic acid.
D. Fernandes
,
S. Cranford
Cancer Research
1986
Corpus ID: 21206735
The effects of 5-fluoro-2'-deoxyuridine (FdUrd) and 5,8-dideazaisofolic acid on the coordination of thymidylate synthase activity…
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1982
1982
Biochemical correlates of responsiveness and collateral sensitivity of some methotrexate-resistant murine tumors to the lipophilic antifolate, metoprine.
F. Sirotnak
,
D. M. Moccio
,
L. J. Goutas
,
L. Kelleher
,
J. Montgomery
Cancer Research
1982
Corpus ID: 5859309
The M5076 murine "ovarian" tumor which is naturally refractive to methotrexate was found to be highly responsive to the…
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1980
1980
Phase I trial of metoprine in patients with advanced cancer.
V. Currie
,
S. Kempin
,
C. Young
Cancer treatment reports
1980
Corpus ID: 3044773
The effects of metoprine administered orally every 2 weeks were studied in 71 evaluable adult patients with advanced malignant…
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1978
1978
Comparison of the antitumor activity and toxicity of 2,4-diamino-5-(1-adamantyl)-6-methylpyrimidine and 2,4-diamino-5-(1-adamantyl)-6-ethylpyrimidine.
S. Zakrzewski
,
C. Dave
,
F. Rosen
Journal of the National Cancer Institute
1978
Corpus ID: 19537863
The effects of two new compounds, 2,4-diamino-5-(1-adamantyl)-6-methylpyrimidine (DAMP) and 2,4-diamino-5-(1-adamantyl)-6…
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1978
1978
Phase I study of DDMP (2,4-diamino-5-(3',4')dichlorophenyl-6 methylpyrimidine) and folinic acid (CF) administration
R. Jager
,
J. Rodzynek
,
J. Klastersky
,
Y. Kenis
1978
Corpus ID: 92032660
1978
1978
Comparison of metoprine (DDMP) and etoprine (DDEP) by measuring the inhibition of deoxyuridine incorporation into the DNA of human leukemic cells 1,2,3.
J. Laszlo
,
M. Fyfe
,
D. Swedwick
,
L. Lee
,
O. Brown
Cancer treatment reports
1978
Corpus ID: 8129248
In vitro studies were used to measure the incorporation of labeled deoxyuridine into the DNA of human leukemic cells in…
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1977
1977
DDMP and selective folinic acid protection in the treatment of malignant disease: a further report.
L. A. Price
,
B. Hill
,
J. Goldie
Clinics in oncology
1977
Corpus ID: 39700325
1976
1976
Experimental chemotherapy with 5-arylpyrimidine antifolates: preliminary studies on toxicity and responsiveness of sarcoma 180 to DDMP (NSC-19494) and DDMP with citrovorum factor (NSC-3590).
F. Sirotnak
,
D. Dorick
,
D. M. Moccio
Cancer treatment reports
1976
Corpus ID: 28186907
The 5-arylpyrimidine antifolate DDMP showed appreciable therapeutic activity against an ascitic form of Sarcoma 180 in BD2F1 mice…
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