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metoprine

Known as: 2,4-diamino-5-(3',4'-dichlorophenyl)-6-methylpyrimidine, DDMP, methodichlorophen 
A diaminopyrimidine folate antagonist with potential antineoplastic activity. Metoprine inhibits dihydrofolate reductase, resulting in decreased… Expand
National Institutes of Health

Papers overview

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Highly Cited
2007
Highly Cited
2007
Many natural compounds have been shown to prevent cancer cell growth through the redox regulation of transcription factors. NF-κB… Expand
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Highly Cited
2006
Highly Cited
2006
The bitterness of a saponin mixture (containing saponin B and DDMP (2,3-dihydro-2,5-dihydroxy-6-methyl-4H-pyran-4-one) saponin in… Expand
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Highly Cited
2005
Highly Cited
2005
Growing interest in plant secondary metabolites has brought with it the need for economical, rapidandefficientextractionprotocols… Expand
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Highly Cited
2005
Highly Cited
2005
Soyasaponins are phytochemicals of major interest for health. Their identification and quantification remain difficult owing to… Expand
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Highly Cited
2004
Highly Cited
2004
Diabetes disease management programs (DDMPs) are proliferating, but their effectiveness in improving quality and mitigating… Expand
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Highly Cited
2000
Highly Cited
2000
An extract was prepared from a commercial soybean-processing by-product (soybean molasses) and was fractionated into purified… Expand
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Review
1998
Review
1998
Saponins can be found in more than one hundred plant families and in some marine animals. However, chemical investigation of… Expand
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Highly Cited
1997
Highly Cited
1997
Aqueous solution of glucose and glycine was heated under reflux for 4 h and extracted with ethyl acetate. Reversed phase HPLC of… Expand
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Highly Cited
1984
Highly Cited
1984
Methotrexate (MTX)-resistant human breast cancer cells (MTXR ZR-75) were obtained following serial passage of the wild-type ZR-75… Expand
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Highly Cited
1983
Highly Cited
1983
Methotrexate (MTX)-resistant sublines of malignant human cells were selected in vitro by stepwise increase in drug concentration… Expand
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