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The complex links between dietary phytochemicals and human health deciphered by metabolomics.
TLDR
The current methods used to evaluate intake of phytochemicals and their effects on health are reviewed and the applications of metabolomics are described, which illustrate the potential of a global approach to explore the complex relationships linking phytochemical intake and metabolism and health. Expand
Urinary metabolites as biomarkers of polyphenol intake in humans: a systematic review.
TLDR
These data confirm the value of certain urinary polyphenols as biomarkers of intake and a validation in populations is now needed to evaluate their specificity, sensitivity, and responsiveness to dose under free-living conditions. Expand
Mass spectrometry-based metabolomics for the discovery of biomarkers of fruit and vegetable intake: citrus fruit as a case study.
TLDR
It is proposed that urine profiling of cohort subjects stratified by consumption is an effective strategy for discovery of sensitive biomarkers of consumption for a wide range of foods. Expand
Dereplication strategies in natural product research: How many tools and methodologies behind the same concept?
TLDR
Five distinct dereplication workflows that can be characterized by the nature of starting materials, by the selected analytical technique, and above all by the final objective are brought to light. Expand
Effects of fermentation on the phytochemical composition and antioxidant properties of soy germ.
TLDR
The antioxidant properties of fermented soy germ samples periodically taken during the fermentation process were evaluated and correlated with the concentration and structural modifications of isoflavones, saponins, phytosterols and tocopherols. Expand
Rhamnolipids Elicit Defense Responses and Induce Disease Resistance against Biotrophic, Hemibiotrophic, and Necrotrophic Pathogens That Require Different Signaling Pathways in Arabidopsis and
TLDR
It is reported that RLs trigger an immune response in Arabidopsis (Arabidopsis thaliana) characterized by signaling molecules accumulation and defense gene activation, which highlights the intricate mechanisms involved in plant protection triggered by a new type of molecule that can be perceived by plant cells and that can also act directly onto pathogens. Expand
Methods of assessment of magnesium status in humans: a systematic review.
TLDR
In conclusion, although limited data were available, serum/plasma magnesium concentration, RBC magnesium concentration and urinary magnesium excretion appear to be useful biomarkers of magnesium status in the general population. Expand
Ablation of Succinate Production from Glucose Metabolism in the Procyclic Trypanosomes Induces Metabolic Switches to the Glycerol 3-Phosphate/Dihydroxyacetone Phosphate Shuttle and to Proline
TLDR
The inability of the Δpepck mutant to maintain a high glycolytic flux demonstrates that the Gly-3-P/DHAP shuttle is not adapted to the procyclic trypanosome context. Expand
Two new bis-iridoids isolated from Scabiosa stellata and their antibacterial, antioxidant, anti-tyrosinase and cytotoxic activities.
TLDR
This study presents the chemical profile investigation of a 70% ethanol extract obtained from Scabiosa stellata, a medicinal herbaceous traditionally used to treat heel cracks, using a 13C NMR-based dereplication methodology and semi-preparative high-performance liquid chromatography. Expand
Transketolase in Trypanosoma brucei.
TLDR
Subcellular localisation experiments revealed that while the protein was present in glycosomes it was found mainly within the cytosol and thus has a dual localisation, indicating a strong differential regulation in the Trypanosoma brucei life cycle. Expand
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