methylnaltrexone

Known as: 17-(Cyclopropylmethyl)-4,5alpha-epoxy-3,14-dihydroxy-17-methyl-6-oxomorphinanium, morphinanium, 17-(cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxy-17-methyl-6-oxo-, (5alpha)-, (5alpha)-17-(cyclopropylmethyl)-3,14-dihydroxy-17-methyl-4,5-epoxymorphinan-17-ium-6-one 
A methyl derivative of noroxymorphone with selective, opioid-receptor antagonistic activity. Methylnaltrexone displaces opioids from peripheral… (More)
National Institutes of Health

Papers overview

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Highly Cited
2011
Highly Cited
2011
UNLABELLED Methylnaltrexone is effective for opioid-induced constipation (OIC) in advanced illness patients. This 4-week, double… (More)
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Highly Cited
2009
Highly Cited
2009
Methylnaltrexone, a peripheral mu-opioid receptor antagonist with restricted ability to cross the blood-brain barrier, may… (More)
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2009
2009
Methylnaltrexone, a peripherally acting mu-opioid receptor antagonist with restricted ability to cross the blood-brain barrier… (More)
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Highly Cited
2008
Highly Cited
2008
Methylnaltrexone, a peripherally-acting quaternary opioid antagonist, is an investigational treatment for opioid-induced… (More)
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Highly Cited
2007
Highly Cited
2007
Endothelial cell (EC) barrier dysfunction (i.e., increased vascular permeability) is observed in inflammatory states, tumor… (More)
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Highly Cited
2006
Highly Cited
2006
Angiogenesis or the formation of new blood vessels is important in the growth and metastatic potential of various cancers… (More)
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Review
2003
Review
2003
Opioid treatment for postoperative or chronic pain is frequently associated with adverse effects, the most common being dose… (More)
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2002
2002
Methylnaltrexone, the first peripheral opioid receptor antagonist, has the potential to prevent or reverse opioid-induced… (More)
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Highly Cited
2000
Highly Cited
2000
CONTEXT Constipation is the most common chronic adverse effect of opioid pain medications in patients who require long-term… (More)
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Highly Cited
1996
Highly Cited
1996
Methylnaltrexone is a quaternary opioid antagonist with limited ability to cross the blood-brain barrier and the potential to… (More)
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