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methylnaltrexone

Known as: 17-(Cyclopropylmethyl)-4,5alpha-epoxy-3,14-dihydroxy-17-methyl-6-oxomorphinanium, morphinanium, 17-(cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxy-17-methyl-6-oxo-, (5alpha)-, (5alpha)-17-(cyclopropylmethyl)-3,14-dihydroxy-17-methyl-4,5-epoxymorphinan-17-ium-6-one 
A methyl derivative of noroxymorphone with selective, opioid-receptor antagonistic activity. Methylnaltrexone displaces opioids from peripheral… 
National Institutes of Health

Related topics

Related topics

9 relations
0.6 ML Methylnaltrexone bromide 20 MG/ML Injection0.6 ML Methylnaltrexone bromide 20 MG/ML Prefilled SyringeMethylnaltrexone bromideMethylnaltrexone bromide 150 MG Oral Tablet [Relistor]

Broader (2)

NaltrexoneNarcotic Antagonists

Narrower (1)

Relistor

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2011
Highly Cited
2011
Safety and Efficacy of Methylnaltrexone in Shortening the Duration of Postoperative Ileus Following Segmental Colectomy: Results of Two Randomized, Placebo-Controlled Phase 3 Trials
PURPOSE: Postoperative ileus contributes to surgical morbidity and is associated with prolonged hospitalization and increased… 
Review
2007
Review
2007
A review of methylnaltrexone, a peripheral opioid receptor antagonist, and its role in opioid-induced constipation
Objectives: Opioid medications are frequently used in pain and palliative care patients with malignancy to manage symptoms such… 
1998
1998
Prevention of apomorphine- or cisplatin-induced emesis in the dog by a combination of methylnaltrexone and morphine
Purpose: Morphine can have either an emetic or an antiemetic effect. The emetic effect of morphine can be blocked by… 
1996
1996
Perinatal treatment of rats with opiates affects the development of the blood-brain barrier transport system PTS-1.
1994
1994
Efficacy of Methylnaltrexone Versus Naloxone for Reversal of Morphine‐Induced Depression of Hypoxic Ventilatory Response
Methylnaltrexone (MNTX) is a quaternary derivative of naltrexone. It does not cross the blood-brain barrier and, thus, it… 
1992
1992
Modulation of immune status by a conditioned aversive stimulus: Evidence for the involvement of endogenous opioids
Highly Cited
1989
Highly Cited
1989
Variations in demethylation of N-methylnaltrexone in mice, rats, dogs, and humans.
1. Rats and mice have a greater capacity than dogs or humans to N-demethylate the quaternary ammonium compound, N… 
1988
1988
Morphine Preexposure attenuates the aversive properties of opiates without preexposure to the aversive properties
1985
1985
Narcotic antagonist-induced hypotension in the spontaneously hypertensive rat.
Highly Cited
1983
Highly Cited
1983
Reversal of morphine-induced catalepsy in the rat by narcotic antagonists and their quaternary derivatives
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