Methylnaltrexone bromide

Known as: naltrexone MB, morphinan-17-ium-6-one, 17-(cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxy-17-methyl-, bromide, (5alpha,17R)-, N-methylnaltrexone bromide 
The bromide salt form of methylnaltrexone, a methyl derivative of noroxymorphone with selective, peripherally-acting mu-opioid receptor antagonistic… (More)
National Institutes of Health

Papers overview

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2011
2011
BACKGROUND Methylnaltrexone, a selective peripheral acting mu-opioid receptor antagonist, alleviates the constipating effects of… (More)
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2010
2010
BACKGROUND Opioid-induced constipation is a common adverse event in patients with advanced illness and has a significant negative… (More)
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2000
2000
BACKGROUND Methylnaltrexone is the first peripheral opioid receptor antagonist. It has the potential to prevent or reverse the… (More)
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1997
1997
N-methylnaltrexone bromide (methylnaltrexone) is a quaternary opioid antagonist with a limited ability to cross the blood-brain… (More)
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1996
1996
Exposure to stress can induce analgesia in the formalin test for tonic pain. Here, we report that blockade of opioid receptors by… (More)
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1996
1996
This research investigated the effect of an increase or decrease in opioid activity in the ventral tegmental area (VTA) on the… (More)
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1994
1994
The possible involvement of opioid receptors in mediating the inhibitory effects of immobilization stress on testicular… (More)
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1989
1989
Naloxone and naltrexone were compared with their quaternary analogues naloxone methobromide and naltrexone methobromide for… (More)
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1987
1987
Enkephalin-containing neuronal fibers and perikarya, and opioid receptors are present in the A10 dopamine (DA) region, and many… (More)
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1985
1985
The discriminative stimulus effects of centrally administered morphine were characterized in rats trained to discriminate 3.0 mg… (More)
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