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Molecular basis of resistance to azole antifungals.
TLDR
The adaptative changes in fungi, in particular Candida albicans, in response to inhibitors of ergosterol biosynthesis are reviewed to help in devising more effective antifungal therapies.
Transcription analysis of human equilibrative nucleoside transporter-1 predicts survival in pancreas cancer patients treated with gemcitabine.
TLDR
It is suggested that the expression levels of hENT1 may allow the stratification of patients based on their likelihood of survival, thus offering a potential new tool for treatment optimization.
Correlation of CDA, ERCC1, and XPD Polymorphisms with Response and Survival in Gemcitabine/Cisplatin–Treated Advanced Non–Small Cell Lung Cancer Patients
TLDR
The role of CDA Lys27Lys polymorphism is suggested as a possible predictive marker of activity, toxicity, TTP, and OS in advanced NSCLC patients treated with cisplatin and gemcitabine.
Biweekly chemotherapy with oxaliplatin, irinotecan, infusional Fluorouracil, and leucovorin: a pilot study in patients with metastatic colorectal cancer.
TLDR
This biweekly chemotherapy regimen with oxaliplatin, L-OHP, irinotecan, infusional fluorouracil, and leucovorin in metastatic colorectal cancer patients is feasible and has acceptable and manageable toxicities and no apparent relevant pharmacokinetics interactions.
Regulation of enteric functions by adenosine: pathophysiological and pharmacological implications.
TLDR
The present review illustrates current information on the role played by adenosine in the regulation of enteric functions, under normal or pathological conditions, and discusses pharmacological interventions onAdenosine pathways as novel therapeutic options for the management of gut disorders and related abdominal symptoms.
An improved HPLC method for therapeutic drug monitoring of daunorubicin, idarubicin, doxorubicin, epirubicin, and their 13-dihydro metabolites in human plasma.
TLDR
Overall results indicate that it is feasible to analyze all the anthracyclines used in clinical practice and their major metabolites with a single optimized method, thereby simplifying their monitoring in chemotherapeutic regimens of cancer patients.
Cyclophosphamide-methotrexate 'metronomic' chemotherapy for the palliative treatment of metastatic breast cancer. A comparative pharmacoeconomic evaluation.
TLDR
Low-dose cyclophosphamide-methotrexate 'metronomic' therapy was assessed to be a cost-effective/cost-saving therapy for palliative treatment for metastatic breast cancer when compared with novel chemotherapy strategies (phase II trials).
Pharmacogenetics of anticancer drug sensitivity in pancreatic cancer
TLDR
The future challenge of pancreas cancer chemotherapy relies on the identification of molecular markers that help in the selection of drugs best suited to the individual patient, and pharmacogenetics is likely to play a central role in the personalization of treatment.
Atorvastatin Prevents Endothelial Dysfunction in Mesenteric Arteries From Spontaneously Hypertensive Rats: Role of Cyclooxygenase 2–Derived Contracting Prostanoids
TLDR
Atorvastatin restores NO availability by increasing phosphorylated extracellular signal–regulated kinase 1/2, pAkt, peNOS1177, and inducible NO synthase levels and by abrogating vascular NADPH oxidase–driven superoxide production, which also results in a downregulation of COX-2–dependent 8-isoprostane generation.
Pharmacokinetics of azithromycin in serum, bronchial washings, alveolar macrophages and lung tissue following a single oral dose of extended or immediate release formulations of azithromycin.
TLDR
By achieving high azithromycin exposure early in the course of treatment, without compromising tolerability, azityromycin-ER shows the potential for improved antibacterial efficacy compared with azithomorphcin-IR.
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