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Gastric antisecretory role and immunohistochemical localization of cannabinoid receptors in the rat stomach
The results indicate that gastric antisecretory effects of cannabinoids in the rat are mediated by suppression of vagal drive to the stomach through activation of CB1 receptors, located on pre‐ and postganglionic cholinergic pathways. Expand
Pharmacokinetics of Tramadol and its Metabolites M1, M2 and M5 in Horses Following Intravenous, Immediate Release (Fasted/Fed) and Sustained Release Single Dose Administration
Abstract Tramadol (T) is a centrally acting analgesic structurally related to codeine and morphine. This drug displays a weak affinity for the μ and δ-opioid receptors, and weaker affinity for theExpand
Pharmacokinetics of enrofloxacin in the seabass (Dicentrarchus labrax)
Abstract The plasma kinetics and tissue distribution of enrofloxacin (EF) were investigated in the seabass (Dicentrarchus labrax) after administration by oral gavage and by bath. Plasma and tissueExpand
Mycotoxin detection in infant formula milks in Italy
The Scientific Committee for Food (SCF) concluded that it would be prudent to reduce exposure to OTA ensuring that exposure is towards the lower end of the range of tolerable daily intakes of 1.2–14 ng kg−1 body weight day−1. Expand
Antimicrobial susceptibility of Staphylococcus intermedius and Staphylococcus schleiferi isolated from dogs.
Although the results confirm susceptibility to antimicrobials currently employed in pyoderma treatment, the several different resistance patterns observed for S. intermedius emphasize the importance of antimicrobial susceptibility testing of canine staphylococci to choose the most appropriate treatment of infections and to allow the prudent use of antimacterial drugs in companion animals. Expand
High growth rate of girls with precocious puberty exposed to estrogenic mycotoxins.
Mycoestrogenic zearalenone is suspected to be a triggering factor for CPP development in girls and may also represent a growth promoter in exposed patients. Expand
Neurokinin receptors and mucosal ion transport in porcine jejunum.
Examination of the pharmacological mechanisms by which SP and its endogenous homologs NKA and NKB affect active electrolyte transport in the mucosa of porcine jejunum found that NK peptides increased contractility in longitudinally oriented strips of jejunal smooth muscle and SP-induced contractions were reduced. Expand
Effects of 17β-estradiol, 4-nonylphenol and PCB 126 on the estrogenic activity and phase 1 and 2 biotransformation enzymes in male sea bass (Dicentrarchus labrax)
The results of this study suggest that the exposure of fish to xenoestrogens or anti-estrogens may alter, in addition to various physiological processes, the expression of specific CYPs and phase 2 enzymes, thereby reducing the capability of their detoxication system. Expand
Antimicrobial susceptibility and mechanism of resistance to fluoroquinolones in Staphylococcus intermedius and Staphylococcus schleiferi.
This study is the first to screen FQs of the second, third and fourth generation for antimicrobial resistance in clinical isolates of S. intermedius and S. schleiferi of canine origin, and to describe mutations in gyrA and grlA associated with FQ resistance in these bacterial species. Expand
Enrofloxacin-theophylline interaction: influence of enrofloxacin on theophylline steady-state pharmacokinetics in the beagle dog.
The kinetic interaction between theophylline and enrofloxacin could be of clinical significance and may require plasma drug concentration monitoring and adjustment of theophyLLine dosage. Expand