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Naltrexone

Known as: 17-(Cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxymorphinan-6-one, Naltrexonum, N-Cyclopropylmethylnoroxymorphone 
A noroxymorphone derivative with competitive opioid antagonistic property. Naltrexone reverses the effects of opioid analgesics by binding to the… 
National Institutes of Health

Related topics

Related topics

46 relations

Narrower (33)

10-ketonaltrexone3-carboxamido-4-hydroxynaltrexone6 beta-hydroxynaltrexone6-deoxy-6-fluoronaltrexone
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Broader (2)

Heterocyclic Compounds, Bridged-RingNarcotic Antagonists
In BloodLiver FailureNaltrexone 380 MG Injection [Vivitrol]Naltrexone cutoff:MCnc:Pt:Urine:Qn:Confirm
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Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2006
Highly Cited
2006
Injectable, sustained-release naltrexone for the treatment of opioid dependence: a randomized, placebo-controlled trial.
CONTEXT Oral naltrexone can completely antagonize the effects produced by opioid agonists. However, poor compliance with… 
Highly Cited
2005
Highly Cited
2005
Efficacy and tolerability of long-acting injectable naltrexone for alcohol dependence: a randomized controlled trial.
CONTEXT Alcohol dependence is a common disorder associated with significant morbidity and mortality. Naltrexone, an opioid… 
Review
2004
Review
2004
Efficacy and safety of naltrexone and acamprosate in the treatment of alcohol dependence: a systematic review.
AIMS To ascertain the efficacy and safety of naltrexone and acamprosate in the treatment of alcohol dependence. METHODS… 
Highly Cited
2003
Highly Cited
2003
A Functional Polymorphism of the μ-Opioid Receptor Gene is Associated with Naltrexone Response in Alcohol-Dependent Patients
This study examined the association between two specific polymorphisms of the gene encoding the μ-opioid receptor and treatment… 
Highly Cited
2002
Highly Cited
2002
Naltrexone decreases craving and alcohol self-administration in alcohol-dependent subjects and activates the hypothalamo–pituitary–adrenocortical axis
Abstract.Background: This laboratory study investigated the mechanisms by which the opioid antagonist, naltrexone, reduces the… 
Highly Cited
2001
Highly Cited
2001
Naltrexone in the treatment of alcohol dependence.
BACKGROUND Although naltrexone, an opiate-receptor antagonist, has been approved by the Food and Drug Administration for the… 
Highly Cited
2001
Highly Cited
2001
Efficacy of naltrexone and acamprosate for alcoholism treatment: a meta-analysis.
BACKGROUND Renewed interest in medications to prevent relapse in alcoholics (i.e., antidipsotropics) resulted in approval by the… 
Highly Cited
1992
Highly Cited
1992
Naltrexone and coping skills therapy for alcohol dependence. A controlled study.
Ninety-seven alcohol-dependent patients were treated for 12 weeks in a double-blind, placebo-controlled study evaluating… 
Highly Cited
1976
Highly Cited
1976
The effects of morphine- and nalorphine- like drugs in the nondependent and morphine-dependent chronic spinal dog.
Three different syndromes produced by congeners of morphine have been identified in the nondependent chronic spinal dog. These… 
Highly Cited
1975
Highly Cited
1975
Isolation of an endogenous compound from the brain with pharmacological properties similar to morphine
  • J. Hughes
  • Brain Research
  • 1975
  • Corpus ID: 42397265
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