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Naltrexone

Known as: 17-(Cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxymorphinan-6-one, Naltrexonum, N-Cyclopropylmethylnoroxymorphone 
A noroxymorphone derivative with competitive opioid antagonistic property. Naltrexone reverses the effects of opioid analgesics by binding to the… 
National Institutes of Health

Related topics

Related topics

46 relations

Narrower (33)

10-ketonaltrexone3-carboxamido-4-hydroxynaltrexone6 beta-hydroxynaltrexone6-deoxy-6-fluoronaltrexone

Broader (2)

Heterocyclic Compounds, Bridged-RingNarcotic Antagonists
In BloodLiver FailureNaltrexone 380 MG Injection [Vivitrol]Naltrexone cutoff:MCnc:Pt:Urine:Qn:Confirm

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2003
Highly Cited
2003
A Functional Polymorphism of the μ-Opioid Receptor Gene is Associated with Naltrexone Response in Alcohol-Dependent Patients
This study examined the association between two specific polymorphisms of the gene encoding the μ-opioid receptor and treatment… 
Highly Cited
2002
Highly Cited
2002
Naltrexone decreases craving and alcohol self-administration in alcohol-dependent subjects and activates the hypothalamo–pituitary–adrenocortical axis
Abstract.Background: This laboratory study investigated the mechanisms by which the opioid antagonist, naltrexone, reduces the… 
Highly Cited
2000
Highly Cited
2000
Naltrexone does not relieve uremic pruritus: results of a randomized, double-blind, placebo-controlled crossover study.
Improvement of uremic pruritus was reported under short-term administration of the mu-receptor antagonists naltrexone and… 
Review
1999
Review
1999
Role of maintenance treatment in opioid dependence
Highly Cited
1997
Highly Cited
1997
Oral naltrexone treatment for cholestatic pruritus: a double-blind, placebo-controlled study.
BACKGROUND & AIMS The efficacy of currently available therapeutic agents for cholestatic pruritus is often disappointing. The aim… 
Highly Cited
1995
Highly Cited
1995
Effect of naltrexone on alcohol "high" in alcoholics.
OBJECTIVE Subjective effects of alcohol in alcoholics treated with naltrexone or placebo were compared. METHOD In a previously… 
Highly Cited
1992
Highly Cited
1992
Naltrexone and coping skills therapy for alcohol dependence. A controlled study.
Ninety-seven alcohol-dependent patients were treated for 12 weeks in a double-blind, placebo-controlled study evaluating… 
Highly Cited
1979
Highly Cited
1979
Alcoholism and Treatment
The Rand report achieved coast to coast media coverage and generated a lot of heat simply because it was found that, out there in… 
Highly Cited
1979
Highly Cited
1979
Relation of endogenous opioid peptides and morphine to neuroendocrine functions.
Highly Cited
1977
Highly Cited
1977
Stimulation of food intake by muscimol and beta endorphin
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