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Naltrexone
Known as:
17-(Cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxymorphinan-6-one
, Naltrexonum
, N-Cyclopropylmethylnoroxymorphone
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A noroxymorphone derivative with competitive opioid antagonistic property. Naltrexone reverses the effects of opioid analgesics by binding to the…
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National Institutes of Health
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Related topics
Related topics
46 relations
Narrower (33)
10-ketonaltrexone
3-carboxamido-4-hydroxynaltrexone
6 beta-hydroxynaltrexone
6-deoxy-6-fluoronaltrexone
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Broader (2)
Heterocyclic Compounds, Bridged-Ring
Narcotic Antagonists
In Blood
Liver Failure
Naltrexone 380 MG Injection [Vivitrol]
Naltrexone cutoff:MCnc:Pt:Urine:Qn:Confirm
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2006
Highly Cited
2006
Injectable, sustained-release naltrexone for the treatment of opioid dependence: a randomized, placebo-controlled trial.
S. Comer
,
M. Sullivan
,
+5 authors
C. O'brien
Archives of General Psychiatry
2006
Corpus ID: 23998556
CONTEXT Oral naltrexone can completely antagonize the effects produced by opioid agonists. However, poor compliance with…
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Highly Cited
2005
Highly Cited
2005
Efficacy and tolerability of long-acting injectable naltrexone for alcohol dependence: a randomized controlled trial.
J. Garbutt
,
H. Kranzler
,
+5 authors
Elliot W. Ehrich
JAMA
2005
Corpus ID: 18418886
CONTEXT Alcohol dependence is a common disorder associated with significant morbidity and mortality. Naltrexone, an opioid…
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Review
2004
Review
2004
Efficacy and safety of naltrexone and acamprosate in the treatment of alcohol dependence: a systematic review.
C. Bouza
,
M. Angeles
,
A. Muñoz
,
J. Amate
Addiction
2004
Corpus ID: 19556258
AIMS To ascertain the efficacy and safety of naltrexone and acamprosate in the treatment of alcohol dependence. METHODS…
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Highly Cited
2003
Highly Cited
2003
A Functional Polymorphism of the μ-Opioid Receptor Gene is Associated with Naltrexone Response in Alcohol-Dependent Patients
D. Oslin
,
W. Berrettini
,
+4 authors
C. O'brien
Neuropsychopharmacology
2003
Corpus ID: 24550936
This study examined the association between two specific polymorphisms of the gene encoding the μ-opioid receptor and treatment…
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Highly Cited
2002
Highly Cited
2002
Naltrexone decreases craving and alcohol self-administration in alcohol-dependent subjects and activates the hypothalamo–pituitary–adrenocortical axis
S. O'Malley
,
S. Krishnan-Sarin
,
C. Farren
,
R. Sinha
,
M. Kreek
Psychopharmacology
2002
Corpus ID: 237427
Abstract.Background: This laboratory study investigated the mechanisms by which the opioid antagonist, naltrexone, reduces the…
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Highly Cited
2001
Highly Cited
2001
Naltrexone in the treatment of alcohol dependence.
J. Krystal
,
J. Cramer
,
W. Krol
,
G. Kirk
,
R. Rosenheck
New England Journal of Medicine
2001
Corpus ID: 20367677
BACKGROUND Although naltrexone, an opiate-receptor antagonist, has been approved by the Food and Drug Administration for the…
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Review
1994
Review
1994
Naltrexone in the treatment of alcohol dependence.
N. O'mara
,
L. Wesley
The Annals of Pharmacotherapy
1994
Corpus ID: 6672913
Highly Cited
1992
Highly Cited
1992
Naltrexone and coping skills therapy for alcohol dependence. A controlled study.
S. O'Malley
,
A. J. Jaffe
,
G. Chang
,
R. Schottenfeld
,
R. Meyer
,
B. Rounsaville
Archives of General Psychiatry
1992
Corpus ID: 34424256
Ninety-seven alcohol-dependent patients were treated for 12 weeks in a double-blind, placebo-controlled study evaluating…
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Highly Cited
1976
Highly Cited
1976
The effects of morphine- and nalorphine- like drugs in the nondependent and morphine-dependent chronic spinal dog.
W. Martin
,
C. G. Eades
,
J. Thompson
,
R. E. Huppler
,
P. Gilbert
Journal of Pharmacology and Experimental…
1976
Corpus ID: 42951562
Three different syndromes produced by congeners of morphine have been identified in the nondependent chronic spinal dog. These…
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Highly Cited
1975
Highly Cited
1975
Isolation of an endogenous compound from the brain with pharmacological properties similar to morphine
J. Hughes
Brain Research
1975
Corpus ID: 42397265
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