Naltrexone

Known as: 17-(Cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxymorphinan-6-one, Naltrexonum, N-Cyclopropylmethylnoroxymorphone 
A noroxymorphone derivative with competitive opioid antagonistic property. Naltrexone reverses the effects of opioid analgesics by binding to the… (More)
National Institutes of Health

Related topics

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46 relations

Narrower (32)

10-ketonaltrexone3-carboxamido-4-hydroxynaltrexone6 beta-hydroxynaltrexone6-deoxy-6-fluoronaltrexone
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Broader (3)

Heterocyclic Compounds, Bridged-RingMorphinansNarcotic Antagonists
In BloodLiver FailureNaltrexone 380 MG Injection [Vivitrol]Naltrexone:PrThr:Pt:Urine:Ord
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Papers overview

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Highly Cited
2010
Highly Cited
2010
Effect of naltrexone plus bupropion on weight loss in overweight and obese adults (COR-I): a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial
BACKGROUND Despite increasing public health concerns regarding obesity, few safe and effective drug treatments are available… (More)
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Highly Cited
2008
Highly Cited
2008
Non-stereoselective reversal of neuropathic pain by naloxone and naltrexone: involvement of toll-like receptor 4 (TLR4).
Although activated spinal cord glia contribute importantly to neuropathic pain, how nerve injury activates glia remains… (More)
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Highly Cited
2006
Highly Cited
2006
Injectable, sustained-release naltrexone for the treatment of opioid dependence: a randomized, placebo-controlled trial.
CONTEXT Oral naltrexone can completely antagonize the effects produced by opioid agonists. However, poor compliance with… (More)
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Highly Cited
2005
Highly Cited
2005
Efficacy and tolerability of long-acting injectable naltrexone for alcohol dependence: a randomized controlled trial.
CONTEXT Alcohol dependence is a common disorder associated with significant morbidity and mortality. Naltrexone, an opioid… (More)
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Highly Cited
2003
Highly Cited
2003
A functional polymorphism of the mu-opioid receptor gene is associated with naltrexone response in alcohol-dependent patients.
This study examined the association between two specific polymorphisms of the gene encoding the mu-opioid receptor and treatment… (More)
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Highly Cited
2002
Highly Cited
2002
Naltrexone decreases craving and alcohol self-administration in alcohol-dependent subjects and activates the hypothalamo–pituitary–adrenocortical axis
Background: This laboratory study investigated the mechanisms by which the opioid antagonist, naltrexone, reduces the risk of… (More)
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Highly Cited
2001
Highly Cited
2001
Double-blind naltrexone and placebo comparison study in the treatment of pathological gambling
BACKGROUND The authors' goal was to assess the efficacy and tolerability of naltrexone in the treatment of pathologic gambling… (More)
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Highly Cited
1998
Highly Cited
1998
Suppression of ethanol-reinforced behavior by naltrexone is associated with attenuation of the ethanol-induced increase in dialysate dopamine levels in the nucleus accumbens.
The opiate antagonist naltrexone suppresses ethanol-reinforced behavior in animals and decreases ethanol intake in humans… (More)
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Highly Cited
1994
Highly Cited
1994
Naltrexone-induced alterations in human ethanol intoxication.
OBJECTIVE Outpatient clinical trials with an opioid antagonist, naltrexone, found that this agent reduces relapse drinking in… (More)
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Highly Cited
1992
Highly Cited
1992
Naltrexone and coping skills therapy for alcohol dependence. A controlled study.
Ninety-seven alcohol-dependent patients were treated for 12 weeks in a double-blind, placebo-controlled study evaluating… (More)
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