Naltrexone

Known as: 17-(Cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxymorphinan-6-one, Naltrexonum, N-Cyclopropylmethylnoroxymorphone 
A noroxymorphone derivative with competitive opioid antagonistic property. Naltrexone reverses the effects of opioid analgesics by binding to the… (More)
National Institutes of Health

Papers overview

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Highly Cited
2010
Highly Cited
2010
BACKGROUND Despite increasing public health concerns regarding obesity, few safe and effective drug treatments are available… (More)
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Highly Cited
2008
Highly Cited
2008
Although activated spinal cord glia contribute importantly to neuropathic pain, how nerve injury activates glia remains… (More)
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Highly Cited
2006
Highly Cited
2006
CONTEXT Oral naltrexone can completely antagonize the effects produced by opioid agonists. However, poor compliance with… (More)
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Highly Cited
2005
Highly Cited
2005
CONTEXT Alcohol dependence is a common disorder associated with significant morbidity and mortality. Naltrexone, an opioid… (More)
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Highly Cited
2003
Highly Cited
2003
This study examined the association between two specific polymorphisms of the gene encoding the mu-opioid receptor and treatment… (More)
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Highly Cited
2002
Highly Cited
2002
Background: This laboratory study investigated the mechanisms by which the opioid antagonist, naltrexone, reduces the risk of… (More)
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Highly Cited
2001
Highly Cited
2001
BACKGROUND The authors' goal was to assess the efficacy and tolerability of naltrexone in the treatment of pathologic gambling… (More)
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Highly Cited
1998
Highly Cited
1998
The opiate antagonist naltrexone suppresses ethanol-reinforced behavior in animals and decreases ethanol intake in humans… (More)
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Highly Cited
1994
Highly Cited
1994
OBJECTIVE Outpatient clinical trials with an opioid antagonist, naltrexone, found that this agent reduces relapse drinking in… (More)
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Highly Cited
1992
Highly Cited
1992
Ninety-seven alcohol-dependent patients were treated for 12 weeks in a double-blind, placebo-controlled study evaluating… (More)
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