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Naltrexone

Known as: 17-(Cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxymorphinan-6-one, Naltrexonum, N-Cyclopropylmethylnoroxymorphone 
A noroxymorphone derivative with competitive opioid antagonistic property. Naltrexone reverses the effects of opioid analgesics by binding to the… 
National Institutes of Health

Papers overview

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Highly Cited
2006
Highly Cited
2006
CONTEXT Oral naltrexone can completely antagonize the effects produced by opioid agonists. However, poor compliance with… 
Highly Cited
2005
Highly Cited
2005
CONTEXT Alcohol dependence is a common disorder associated with significant morbidity and mortality. Naltrexone, an opioid… 
Review
2004
Review
2004
AIMS To ascertain the efficacy and safety of naltrexone and acamprosate in the treatment of alcohol dependence. METHODS… 
Highly Cited
2003
Highly Cited
2003
This study examined the association between two specific polymorphisms of the gene encoding the μ-opioid receptor and treatment… 
Highly Cited
2002
Highly Cited
2002
Abstract.Background: This laboratory study investigated the mechanisms by which the opioid antagonist, naltrexone, reduces the… 
Highly Cited
2001
Highly Cited
2001
BACKGROUND Although naltrexone, an opiate-receptor antagonist, has been approved by the Food and Drug Administration for the… 
Highly Cited
2001
Highly Cited
2001
BACKGROUND Renewed interest in medications to prevent relapse in alcoholics (i.e., antidipsotropics) resulted in approval by the… 
Highly Cited
1992
Highly Cited
1992
Ninety-seven alcohol-dependent patients were treated for 12 weeks in a double-blind, placebo-controlled study evaluating… 
Highly Cited
1976
Highly Cited
1976
Three different syndromes produced by congeners of morphine have been identified in the nondependent chronic spinal dog. These…