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3-carboxamido-4-hydroxynaltrexone

Known as: samidorphan 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (1)

Naltrexone
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2020
2020
Olanzapine Plus Samidorphan (ALKS 3831) in Schizophrenia and Comorbid Alcohol Use Disorder: A Phase 2, Randomized Clinical Trial.
OBJECTIVE Alcohol use disorder (AUD) is a common comorbidity of schizophrenia. No effective pharmacologic treatment is available… 
2019
2019
50 Adjunctive Buprenorphine/Samidorphan Combination in Patients with Major Depressive Disorder: Phase 3 Long-term Extension Study Results
Abstract Introduction Buprenorphine/samidorphan (BUP/SAM), a combination of BUP (a µ-opioid receptor partial agonist and… 
2019
2019
Mitigation of Olanzapine-Induced Weight Gain: Not the Sami Old Thing
Promising results from a phase 2 trial of olanzapine plus samidorphan in patients with schizophrenia. 
2019
2019
5 Clinical Evaluation of the Abuse Potential of Buprenorphine/Samidorphan Combination
Abstract Introduction Buprenorphine (BUP)/samidorphan (SAM) combination is an opioid system modulator being investigated as an… 
2019
2019
F160. Samidorphan, an Opioid Receptor Antagonist, Mitigates Olanzapine-Induced Metabolic Dysfunction in Female Rats
2018
2018
S227. A PROPOSED ALTERNATIVE BETWEEN DISCONTINUATION AND MAINTENANCE OF ANTIPSYCHOTICS: A GUIDED DOSE REDUCTION TRIAL FOR PATIENTS WITH REMITTED PSYCHOSIS
Abstract Background Early intervention at the beginning of schizophrenia and related psychotic disorders can get better treatment… 
2018
2018
F233. NEGATIVE SYMPTOMS ARE INDEPENDENT MODERATOR FACTORS OF TREATMENT RESISTANT SCHIZOPHRENIA EFFECTS ON MULTIPLE CLINICAL, PSYCHOPATHOLOGICAL, COGNITIVE AND PSYCHOSOCIAL VARIABLES
Abstract Background Negative symptoms (NSs) are more severe in Treatment Resistant Schizophrenia (TRS) than Antipsychotic… 
2018
2018
S228. TOWARD EARLY DETECTION OF TREATMENT RESISTANT SCHIZOPHRENIA: PREDICTIVE INFORMATION ON NON-RESPONSE TO ANTIPSYCHOTICS BY EVALUATION OF A FEW CLINICAL FACTORS: A STUDY BY ROC CURVE ANALYSIS AND…
Abstract Background Treatment Resistant Schizophrenia (TRS) is associated to poor prognosis and highly disabling course. Early… 
2018
2018
Effectiveness of Samidorphan in Combination with Olanzapine to Mitigate Metabolic Risk
2015
2015
The abuse liability of buprenorphine is blocked by samidorphan, a novel opioid modulator, in rats tested in the intracranial self-stimulation paradigm
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