Ginseng pharmacology: multiple constituents and multiple actions.
Regional Anesthesia in the Patient Receiving Antithrombotic or Thrombolytic Therapy: American Society of Regional Anesthesia and Pain Medicine Evidence-Based Guidelines (Third Edition)
The ASRA consensus statements represent the collective experience of recognized experts in the field of neuraxial anesthesia and anticoagulation and are based on case reports, clinical series, pharmacology, hematology, and risk factors for surgical bleeding.
Regional Anesthesia in the Anticoagulated Patient: Defining the Risks (The Second ASRA Consensus Conference on Neuraxial Anesthesia and Anticoagulation)
Neuraxial anesthesia and analgesia provide several advantages over systemic opioids, including superior analgesia, reduced blood loss and need for transfusion, decreased incidence of graft occlusion,…
Antidiabetic effects of Panax ginseng berry extract and the identification of an effective component.
Antihyperglycemic and anti-obese effects of Panax ginseng berry extract and its major constituent, ginsenoside Re, in obese diabetic C57BL/6J ob/ ob mice and their lean littermates were evaluated, suggesting that other constituents in the extract have distinct pharmacological mechanisms on energy metabolism.
Methylnaltrexone for reversal of constipation due to chronic methadone use: a randomized controlled trial.
It is demonstrated that intravenous methylnaltrexone can induce laxation and reverse slowing of oral cecal-transit time in subjects taking high opioid dosages and may have clinical utility in managing opioid-induced constipation.
Ginsenoside Rh2 induces apoptosis and paraptosis-like cell death in colorectal cancer cells through activation of p53.
American ginseng: potential structure-function relationship in cancer chemoprevention.
Crocin from Crocus sativus possesses significant anti-proliferation effects on human colorectal cancer cells.
Data from this study demonstrated that Crocus sativus extract and its major constituent, crocin, significantly inhibited the growth of colorectal cancer cells while not affecting normal cells.
Tolerability, Gut Effects, and Pharmacokinetics of Methylnaltrexone Following Repeated Intravenous Administration in Humans
This study showed that repeated administration of intravenous methylnaltrexone is well tolerated in humans, with no significant adverse events or changes in opioid subjective ratings and no clinically noteworthy alterations in pharmacokinetics, and suggested that endogenous opioids modulate human gut motility.
Effects of subcutaneous methylnaltrexone on morphine-induced peripherally mediated side effects: a double-blind randomized placebo-controlled trial.
- C. Yuan, G. Wei, J. Foss, M. O'Connor, T. Karrison, J. Osiński
- Medicine, BiologyJournal of Pharmacology and Experimental…
Subcutaneous methylnaltrexone may have clinical utility in treating opioid-induced constipation and reducing morphine-induced unpleasant subjective symptoms and pharmacokinetic data after subcutaneous drug injection were studied.