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Ginseng pharmacology: multiple constituents and multiple actions.
TLDR
This commentary aims to review selected effects of ginseng and ginsenosides and describe their possible modes of action, structural and functional relationship to steroids, and potential targets of action. Expand
Regional Anesthesia in the Patient Receiving Antithrombotic or Thrombolytic Therapy: American Society of Regional Anesthesia and Pain Medicine Evidence-Based Guidelines (Third Edition)
TLDR
The ASRA consensus statements represent the collective experience of recognized experts in the field of neuraxial anesthesia and anticoagulation and are based on case reports, clinical series, pharmacology, hematology, and risk factors for surgical bleeding. Expand
Regional Anesthesia in the Anticoagulated Patient: Defining the Risks (The Second ASRA Consensus Conference on Neuraxial Anesthesia and Anticoagulation)
Neuraxial anesthesia and analgesia provide several advantages over systemic opioids, including superior analgesia, reduced blood loss and need for transfusion, decreased incidence of graft occlusion,Expand
Antidiabetic effects of Panax ginseng berry extract and the identification of an effective component.
TLDR
Antihyperglycemic and anti-obese effects of Panax ginseng berry extract and its major constituent, ginsenoside Re, in obese diabetic C57BL/6J ob/ ob mice and their lean littermates were evaluated, suggesting that other constituents in the extract have distinct pharmacological mechanisms on energy metabolism. Expand
Methylnaltrexone for reversal of constipation due to chronic methadone use: a randomized controlled trial.
TLDR
It is demonstrated that intravenous methylnaltrexone can induce laxation and reverse slowing of oral cecal-transit time in subjects taking high opioid dosages and may have clinical utility in managing opioid-induced constipation. Expand
Ginsenoside Rh2 induces apoptosis and paraptosis-like cell death in colorectal cancer cells through activation of p53.
TLDR
It is shown that Rh2 exhibited significantly more potent cell death activity than the ginsenoside Rg3 in HCT116 and SW480 colorectal cancer cells, suggesting that the anti-cancer effect of Rh2 can be enhanced by antioxidants. Expand
Tolerability, Gut Effects, and Pharmacokinetics of Methylnaltrexone Following Repeated Intravenous Administration in Humans
TLDR
This study showed that repeated administration of intravenous methylnaltrexone is well tolerated in humans, with no significant adverse events or changes in opioid subjective ratings and no clinically noteworthy alterations in pharmacokinetics, and suggested that endogenous opioids modulate human gut motility. Expand
Effects of subcutaneous methylnaltrexone on morphine-induced peripherally mediated side effects: a double-blind randomized placebo-controlled trial.
TLDR
Subcutaneous methylnaltrexone may have clinical utility in treating opioid-induced constipation and reducing morphine-induced unpleasant subjective symptoms and pharmacokinetic data after subcutaneous drug injection were studied. Expand
American ginseng: potential structure-function relationship in cancer chemoprevention.
TLDR
The different ginsenosides in American ginseng, both the naturally occurring compounds and those resulting from steaming or biotransformation are introduced, and the possible structural-function relationship with a focus on sugar molecules, hydroxyl groups and stereoselectivity in gINSenosides is explored. Expand
Crocin from Crocus sativus possesses significant anti-proliferation effects on human colorectal cancer cells.
TLDR
Data from this study demonstrated that Crocus sativus extract and its major constituent, crocin, significantly inhibited the growth of colorectal cancer cells while not affecting normal cells. Expand
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