marizomib

Known as: (1R,4R,5S)-4-(2-chloroethyl)-1-{(S)-[(1S)-cyclohex-2-en-1-yl]hydroxymethyl}-5-methyl-6-oxa-2-azabicyclo[3.2.0]heptane-3,7-dione, Salinosporamide A, Salinosporin A 
A naturally-occurring salinosporamide, isolated from the marine actinomycete Salinospora tropica, with potential antineoplastic activity. Marizomib… (More)
National Institutes of Health

Papers overview

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2017
2017
Marizomib, a natural marine product, is an irreversible proteasome inhibitor currently under investigation in relapsed-refractory… (More)
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2014
Highly Cited
2014
Ixazomib is the first investigational oral proteasome inhibitor to be studied clinically. In this phase 1 trial, 60 patients with… (More)
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2014
2014
The proteasome inhibitor bortezomib is an effective therapy for the treatment of relapsed and refractory multiple myeloma (RRMM… (More)
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2011
2011
Purpose Combining proteasome and histone deacetylase (HDAC) inhibition has been seen to provide synergistic anti-tumor activity… (More)
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2010
2010
The incidence of infections by drug-resistant bacteria continues to increase and remains a serious threat to human health. In… (More)
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2009
2009
The natural proteasome inhibitor salinosporamide A from the marine bacterium Salinispora tropica is a promising drug candidate… (More)
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2008
Highly Cited
2008
BACKGROUND Malaria continues to be a devastating parasitic disease that causes the death of 2 million individuals annually. The… (More)
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2008
2008
In this paper, we described the development of a potassium-chloride-based-salt formulation containing low sodium concentrations… (More)
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2006
Highly Cited
2006
The crystal structures of the yeast 20S proteasome core particle (CP) in complex with Salinosporamides A (NPI-0052; 1) and B (4… (More)
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2005
2005
An extensive study of the secondary metabolites produced by the obligate marine actinomycete Salinispora tropica (strain CNB-392… (More)
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