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Proteasome Function Inhibition

Known as: Proteasome Inhibition 
Proteasome Inhibition involves interference with, or restraint of, the activities of macromolecular multicatalytic cellular structures in the cytosol… 
National Institutes of Health

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Related topics

4 relations
bortezomibixazomibixazomib citratemarizomib

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2009
2009
Myeloma cells exhibit an increase in proteasome activity and an enhanced response to proteasome inhibition in the bone marrow microenvironment in vivo
The proteasome inhibitor bortezomib has a striking clinical benefit in patients with multiple myeloma. It is unknown whether the… 
2006
2006
Proteasome inhibition induces differential heat shock protein response but not unfolded protein response in HepG2 cells
Liver, a central organ responsible for the metabolism of carbohydrates, proteins, and lipoproteins, is exposed to various kinds… 
Highly Cited
2004
Highly Cited
2004
Repeat Sequence of Epstein-Barr Virus-encoded Nuclear Antigen 1 Protein Interrupts Proteasome Substrate Processing*
The Epstein-Barr virus thwarts immune surveillance through a Gly-Ala repeat (GAr) within the viral Epstein-Barr virus-encoded… 
2004
2004
The erythropoietin-receptor pathway modulates survival of cancer cells
Anemia in cancer patients is associated with reduced quality of life and local failure after radiation treatment. However, the… 
Review
2004
Review
2004
Emerging roles of proteasomes in ischemia-reperfusion injury of organs.
Proteasomes are the main non-lysosomal, multicatalytic proteinase complexes involved in the degradation of most intracellular… 
Highly Cited
2002
Highly Cited
2002
Potentiation of glucocorticoid receptor transcriptional activity by sumoylation.
The glucocorticoid receptor (GR) is a transcription factor, subject to several types of posttranslational modifications including… 
Highly Cited
2001
Highly Cited
2001
Proteasome Inhibition Induces Nuclear Translocation and Transcriptional Activation of the Dioxin Receptor in Mouse Embryo Primary Fibroblasts in the Absence of Xenobiotics
ABSTRACT The aryl hydrocarbon receptor (AHR) is a transcription factor that is highly conserved during evolution and shares… 
Highly Cited
1999
Highly Cited
1999
Bivalency as a principle for proteasome inhibition.
The proteasome, a multicatalytic protease, is known to degrade unfolded polypeptides with low specificity in substrate selection… 
1999
1999
Ubiquitin-proteasome inhibition enhances apoptosis of human pancreatic cancer cells.
Highly Cited
1997
Highly Cited
1997
Detailed analysis of cell cycle kinetics upon proteasome inhibition.
We have studied specific effects of proteasome inhibition on cell cycle progression. To this end, the protease inhibitors MG115… 
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