Proteasome Function Inhibition

Known as: Proteasome Inhibition 
Proteasome Inhibition involves interference with, or restraint of, the activities of macromolecular multicatalytic cellular structures in the cytosol… (More)
National Institutes of Health

Related topics

Related topics

4 relations
bortezomibixazomibixazomib citratemarizomib

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2010
Highly Cited
2010
Transcription factor Nrf1 mediates the proteasome recovery pathway after proteasome inhibition in mammalian cells.
In Saccharomyces cerevisiae, chemical or genetic inhibition of proteasome activity induces new proteasome synthesis promoted by… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Review
2008
Review
2008
Proteasome inhibitors in cancer therapy: lessons from the first decade.
The ubiquitin-proteasome pathway is involved in intracellular protein turnover, and its function is crucial to cellular… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2007
Highly Cited
2007
Linking of autophagy to ubiquitin-proteasome system is important for the regulation of endoplasmic reticulum stress and cell viability.
Two major protein degradation systems exist in cells, the ubiquitin proteasome system and the autophagy machinery. Here, we… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2007
Highly Cited
2007
Extensive immunoglobulin production sensitizes myeloma cells for proteasome inhibition.
Multiple myeloma is an incurable plasma cell neoplasia characterized by the production of large amounts of monoclonal… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Review
2006
Review
2006
Bortezomib: proteasome inhibition as an effective anticancer therapy.
VELCADER (bortezomib, Millennium Pharmaceuticals, Inc., Cambridge, MA, and Johnson & Johnson Pharmaceutical Research… (More)
Is this relevant?
Review
2005
Review
2005
Proteasome inhibition as a novel therapeutic target in human cancer.
The 26S proteasome is a large intracellular adenosine 5'-triphosphate-dependent protease that identifies and degrades proteins… (More)
Is this relevant?
Highly Cited
2002
Highly Cited
2002
Molecular sequelae of proteasome inhibition in human multiple myeloma cells.
The proteasome inhibitor PS-341 inhibits IkappaB degradation, prevents NF-kappaB activation, and induces apoptosis in several… (More)
  • figure 1
  • figure 3
  • figure 2
  • figure 4
Is this relevant?
Review
2001
Review
2001
Proteasome inhibition in cancer: development of PS-341.
The 26S proteasome regulates protein turnover in eukaryotic cells. This is relevant in human cancer because the cell cycle, tumor… (More)
Is this relevant?
Highly Cited
2000
Highly Cited
2000
Impaired proteasome function in Alzheimer's disease.
Inhibition of proteasome activity is sufficient to induce neuron degeneration and death; however, altered proteasome activity in… (More)
Is this relevant?
Highly Cited
1999
Highly Cited
1999
Proteasome inhibitors: a novel class of potent and effective antitumor agents.
The ubiquitin-proteasome pathway plays a critical role in the regulated degradation of proteins involved in cell cycle control… (More)
  • table 1
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?