Proteasome Function Inhibition

Known as: Proteasome Inhibition 
Proteasome Inhibition involves interference with, or restraint of, the activities of macromolecular multicatalytic cellular structures in the cytosol… (More)
National Institutes of Health

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Highly Cited
2010
Highly Cited
2010
In Saccharomyces cerevisiae, chemical or genetic inhibition of proteasome activity induces new proteasome synthesis promoted by… (More)
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Review
2008
Review
2008
The ubiquitin-proteasome pathway is involved in intracellular protein turnover, and its function is crucial to cellular… (More)
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Highly Cited
2007
Highly Cited
2007
Two major protein degradation systems exist in cells, the ubiquitin proteasome system and the autophagy machinery. Here, we… (More)
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Highly Cited
2007
Highly Cited
2007
Multiple myeloma is an incurable plasma cell neoplasia characterized by the production of large amounts of monoclonal… (More)
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Review
2006
Review
2006
VELCADER (bortezomib, Millennium Pharmaceuticals, Inc., Cambridge, MA, and Johnson & Johnson Pharmaceutical Research… (More)
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Review
2005
Review
2005
The 26S proteasome is a large intracellular adenosine 5'-triphosphate-dependent protease that identifies and degrades proteins… (More)
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Highly Cited
2002
Highly Cited
2002
The proteasome inhibitor PS-341 inhibits IkappaB degradation, prevents NF-kappaB activation, and induces apoptosis in several… (More)
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Review
2001
Review
2001
The 26S proteasome regulates protein turnover in eukaryotic cells. This is relevant in human cancer because the cell cycle, tumor… (More)
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Highly Cited
2000
Highly Cited
2000
Inhibition of proteasome activity is sufficient to induce neuron degeneration and death; however, altered proteasome activity in… (More)
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Highly Cited
1999
Highly Cited
1999
The ubiquitin-proteasome pathway plays a critical role in the regulated degradation of proteins involved in cell cycle control… (More)
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