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Proteasome Function Inhibition

Known as: Proteasome Inhibition 
Proteasome Inhibition involves interference with, or restraint of, the activities of macromolecular multicatalytic cellular structures in the cytosol… 
National Institutes of Health

Related topics

Related topics

4 relations
bortezomibixazomibixazomib citratemarizomib

Papers overview

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Highly Cited
2018
Highly Cited
2018
UbiSite approach for comprehensive mapping of lysine and N-terminal ubiquitination sites
Ubiquitination is a post-translational modification (PTM) that is essential for balancing numerous physiological processes. To… 
Highly Cited
2012
Highly Cited
2012
Failure of Amino Acid Homeostasis Causes Cell Death following Proteasome Inhibition
Highly Cited
2011
Highly Cited
2011
Nonproteasomal Targets of the Proteasome Inhibitors Bortezomib and Carfilzomib: a Link to Clinical Adverse Events
Purpose: Bortezomib (Velcade), a dipeptide boronate 20S proteasome inhibitor and an approved treatment option for multiple… 
Highly Cited
2009
Highly Cited
2009
A Phase 1 Dose Escalation Study of the Safety and Pharmacokinetics of the Novel Proteasome Inhibitor Carfilzomib (PR-171) in Patients with Hematologic Malignancies
Purpose: Carfilzomib (formerly PR-171) is a novel proteasome inhibitor of the epoxyketone class that is selective and… 
Review
2008
Review
2008
Proteasome Inhibitors in Cancer Therapy: Lessons from the First Decade
The ubiquitin-proteasome pathway is involved in intracellular protein turnover, and its function is crucial to cellular… 
Highly Cited
2007
Highly Cited
2007
Extensive immunoglobulin production sensitizes myeloma cells for proteasome inhibition.
Multiple myeloma is an incurable plasma cell neoplasia characterized by the production of large amounts of monoclonal… 
Highly Cited
2004
Highly Cited
2004
Probiotics inhibit nuclear factor-kappaB and induce heat shock proteins in colonic epithelial cells through proteasome inhibition.
BACKGROUND AND AIMS The extent and severity of mucosal injury in inflammatory bowel diseases are determined by the disequilibrium… 
Highly Cited
2001
Highly Cited
2001
α‐Synuclein metabolism and aggregation is linked to ubiquitin‐independent degradation by the proteasome
Highly Cited
1998
Highly Cited
1998
Tumor growth inhibition induced in a murine model of human Burkitt's lymphoma by a proteasome inhibitor.
Cell growth and viability are dependent on the function of the multicatalytic proteinase complex (proteasome), a multisubunit… 
Highly Cited
1997
Highly Cited
1997
The Degradation of Apolipoprotein B100 Is Mediated by the Ubiquitin-proteasome Pathway and Involves Heat Shock Protein 70*
Apolipoprotein B (apoB) is the major protein component of atherogenic lipoproteins of hepatic origin. In HepG2 cells, the… 
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