B. Potts

Publications64
h-index29
Citations3,635
Highly Influential Citations80
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The odyssey of marine pharmaceuticals: a current pipeline perspective.
Marizomib, a proteasome inhibitor for all seasons: preclinical profile and a framework for clinical trials.
TLDR
This review captures the remarkable translational studies and contributions from many collaborators that have advanced marizomib from seabed to bench to bedside.
Crystal structures of Salinosporamide A (NPI-0052) and B (NPI-0047) in complex with the 20S proteasome reveal important consequences of beta-lactone ring opening and a mechanism for irreversible…
TLDR
The crystal structures of the yeast 20S proteasome core particle (CP) in complex with Salinosporamides A and B were solved and the collective data provide new insights into the mechanism of inhibition and irreversible binding of 1.
NMR of biofluids and pattern recognition: assessing the impact of NMR parameters on the principal component analysis of urine from rat and mouse.
Lynamicins A-E, chlorinated bisindole pyrrole antibiotics from a novel marine actinomycete.
TLDR
A series of chlorinated bisindole pyrroles, lynamicins A-E (1-5), was discovered from a novel marine actinomycete, NPS12745, which was isolated from a marine sediment collected off the coast of San Diego, California, which demonstrated that these substances possess broad-spectrum activity against both Gram-positive and Gram-negative organisms.
Lipoxazolidinones A, B, and C: antibacterial 4-oxazolidinones from a marine actinomycete isolated from a Guam marine sediment.
TLDR
The 2-alkylidene-4-oxazolidinone represents a new antibiotic pharmacophore and is unprecedented in nature.
The structure of calcyclin reveals a novel homodimeric fold for S100 Ca2+-binding proteins
TLDR
The three-dimensional structure of the S100 protein calcyclin has been determined in solution in the apo state by NMR spectroscopy and a computational strategy that incorporates a systematic docking protocol reveals a symmetric homodimeric fold that is unique among calcium-binding proteins.
Discovery and development of the anticancer agent salinosporamide A (NPI-0052).
Phospholipase A2 inhibitors from marine organisms.
TLDR
This review of phospholipase A2 (PLA2) inhibitors from marine organisms presents a compilation of research in this field over the past decade and provides a rationale for seeking inhibitors of PLA2 as anti-inflammatory agents.
6-BROMOTRYPTAMINE DERIVATIVES FROM THE GULF OF CALIFORNIA TUNICATE DIDEMNUM CANDIDUM
TWO slightly different specimens of the encrusting grey tunicate Dihnum candidum were collected in the southern Gulf of California and were examined separately. 6- Bromotryptamine [l] was isolated…
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