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manoalide

National Institutes of Health

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Broader (5)

Anti-Bacterial AgentsAnti-Inflammatory Agents, Non-SteroidalCalcium Channel BlockersPhosphodiesterase Inhibitors

Papers overview

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2007
2007
Production of Manoalide and Its Analogues by the Sponge Luffariella variabilis Is Hardwired
The Great Barrier Reef sponge Luffariella variabilis (Poléjaeff 1884) produces a range of potent anti-inflammatory compounds as… 
2000
2000
Simultaneous Inhibition of Renal Phospholipase A2 and Glutathione Synthesis by Manoalide and DL-Buthionine Sulfoximine Induces Acute Tubular Dysfunction in Rats
We have previously demonstrated that gentamicin-induced acute renal failure is mediated by the consumption of renal glutathione… 
1998
1998
Synthesis and comparison of the antiinflammatory activity of manoalide and cacospongionolide B analogues.
We have synthesized analogues of two naturally occurring antiinflammatory marine compounds, manoalide and cacospongionolide B… 
1996
1996
The effects of the phospholipase A2 inhibitor, manoalide, on cartilage degradation, stromelysin expression, and synovial fluid cell count induced by intraarticular injection of human recombinant…
OBJECTIVE To evaluate the effects of the phospholipase A2 (PLA2) inhibitor manoalide on cartilage degradation, stromelysin… 
1995
1995
Chemical modification and inactivation of phospholipases A2 by a manoalide analogue.
Chemical modification and inactivation of bovine pancreatic, porcine pancreatic, Naja naja atra and Pseudechis australis… 
1994
1994
Marine natural products. XXXII. Absolute configurations of C-4 of the manoalide family, biologically active sesterterpenes from the marine sponge Hyrtios erecta.
Cytotoxic sesterterpenes, manoalide 25-acetals (1a, 1b), seco-manoalide (2), (E)-neomanoalide (3), (Z)-neomanoalide (4), and… 
1994
1994
Mechanically induced calcium mobilization in cultured endothelial cells is dependent on actin and phospholipase.
We sought to evaluate the mechanisms by which mechanical perturbation elevates intracellular calcium in endothelial cells. We… 
1992
1992
Phospholipase activation during monocyte adherence and spreading.
Phospholipase activation is an important element in cellular signal transduction. In our study we investigated the role and… 
1989
1989
Luffolide, a novel anti-inflammatory terpene from the spongeLuffariella sp.
Luffolide (4) is a minor metabolite of the spongeLuffariella sp. from Palau. The structure of luffolide was determined by single… 
Highly Cited
1986
Highly Cited
1986
The role of polyphosphoinositides and their breakdown products in A23187-induced release of arachidonic acid from rabbit polymorphonuclear leucocytes.
Stimulation of rabbit polymorphonuclear leucocytes with A23187 causes phospholipase C mediated breakdown of polyphosphoinositides… 
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