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Enhanced Dystrophic Progression in mdx Mice by Exercise and Beneficial Effects of Taurine and Insulin-Like Growth Factor-1
A preclinical screening for prompt-to-use drugs that are safer than steroids and beneficial in Duchenne muscular dystrophy was performed. Compounds able to reduce calcium-induced degenerationExpand
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A human cellular model for studying the regulation of glucagon-like peptide-1 secretion.
GLP-1 (glucagon-like peptide-1) is a potent insulin secretagogue released from L cells in the intestine. The regulation of GLP-1 secretion has been described both in vivo and in vitro in severalExpand
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Creatine supplementation improves intracellular Ca2+ handling and survival in mdx skeletal muscle cells
Dystrophic skeletal muscle cells from Duchenne muscular dystrophy (DMD) patients and mdx mice exhibit elevated cytosolic Ca2+ concentrations ([Ca2+]c). Pretreatment of mdx myotubes for 6–12 days withExpand
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Receptor‐Operated Calcium‐Permeable Channels in Vascular Smooth Muscle
The extracellular Ca2+ dependence of agonist stimulation of vascular smooth muscle (VSM) has been investigated in rat cultured aortic smooth muscle cells (SMCs) and isolated mesenteric resistanceExpand
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Regulation of cytosolic calcium in skeletal muscle cells of the mdx mouse under conditions of stress
1 In Duchenne muscular dystrophy (DMD) dysregulation of cytosolic calcium appears to be involved in the degeneration of skeletal muscle fibres. Therefore, we have studied the regulation of the freeExpand
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Modulation by prednisolone of calcium handling in skeletal muscle cells
1 Increased calcium (Ca2+) influx has been incriminated as a potential pathological mechanism in the chronic skeletal muscle degeneration exhibited by Duchenne muscular dystrophy (DMD) patients. WeExpand
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Calcium influx inhibition by steroids and analogs in C2C12 skeletal muscle cells
Glucocorticoids, namely α‐methylprednisolone (PDN) and deflazacort, are the only drugs reported to have a beneficial effect on the degenerative course of Duchenne muscular dystrophy (DMD). IncreasedExpand
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A rapid and sensitive assay for arginase.
Abstract An assay for arginase is described that uses l -[ guanido - 14 C]arginine as substrate. Unhydrolyzed arginine is removed in a batch procedure with sulfonate resin and the [ 14 C]urea productExpand
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