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A bifunctional intercalates may intercalate with DMAin at least two ways. Both intercalating moieties may intercalate with the… Expand The luzopeptins are DNA bisintercalating antibiotics that contain a decadepsipeptide to which are attached two quinoline… Expand Abstract The luzopeptin antibiotics contain a cyclic decadepsipeptide to which are attached two quinoline chromophores that… Expand The in vitro sensitivity of Plasmodium falciparum to bleomycin, busulfan, camptothecin, CC-1065, cisplatin, daunomycin… Expand Imino proton exchange studies are reported on the complexes formed by bisintercalation of luzopeptin around the two central A.T… Expand The effect of luzopeptin on the mobility of DNA in polyacrylamide gels has been determined. Experiments on a mixture of DNA… Expand 1H- and 31P-n.m.r. spectroscopy were used to characterize the solution structure of the 1:1 complex formed between the antitumour… Expand We have examined the binding of luzopeptin, an antitumor antibiotic, to five DNA fragments of varying base composition. The drug… Expand The depsipeptide DNA-intercalating antibiotic luzopeptin was studied in solution by n.m.r. methods. Two-dimensional 1H double… Expand Luzopeptin analogues, A, B and C (in decreasing degree of acetylation) were active, less active and inactive, respectively… Expand