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Molecular cloning and sequence analysis of the Plasmodium falciparum dihydrofolate reductase-thymidylate synthase gene.
TLDR
Genomic DNA clones that coded for the bifunctional dihydrofolate reductase (DHFR) and thymidylate synthase (TS) activities from a pyrimethamine-sensitive strain of Plasmodium falciparum were isolated and sequenced and predicted secondary structures were nearly identical to the structures identified in other DHFR and TS enzymes. Expand
Synthesis of DNA during the asexual cycle of Plasmodium falciparum in culture.
DNA synthesis in cultures of tightly synchronized, developing, asexual forms of Plasmodium falciparum began during the early trophozoite stage between 29.5 and 31 h after parasite invasion andExpand
Amino acid sequence of the serine-repeat antigen (SERA) of Plasmodium falciparum determined from cloned cDNA.
TLDR
It is shown, by cDNA nucleotide sequence analysis, that this antigen gene encodes a 989 amino acid protein that contains a potential signal peptide, but not a membrane anchor domain, and is proposed to identity by the acronym SERA, serine-repeat antigen based on its complete structure. Expand
Pyrimethamine resistant Plasmodium falciparum: overproduction of dihydrofolate reductase by a gene duplication.
TLDR
Results suggested that the pyrimethamine resistance was not associated with decreased drug permeability of the membrane and some of the DHFR-TS genetic material in FCR3-D7 is associated with a gene duplication. Expand
Segregation into and Replication of Plasmid Deoxyribonucleic Acid in Chromosomeless Segregants of Escherichia coli
  • J. Inselburg
  • Medicine, Biology
  • Journal of bacteriology
  • 1 June 1970
The progeny cells of Escherichia coli strain P678-54, which normally do not contain deoxyribonucleic acid (DNA), were found to carry DNA when the parental cell carried colicin factor E1 (Col E1). TheExpand
An enlarged largest subunit of Plasmodium falciparum RNA polymerase II defines conserved and variable RNA polymerase domains.
TLDR
The P. falciparum RPII subunit is the largest (2452 amino acids) eukaryotic RP II subunit, and it contains enlarged variable regions that clearly separate and define five conserved regions of the eukARYotic RPII largest subunits. Expand
Stage-specific inhibitory effect of cyclic AMP on asexual maturation and gametocyte formation of Plasmodium falciparum.
  • J. Inselburg
  • Biology, Medicine
  • The Journal of parasitology
  • 1 June 1983
The effect of cyclic AMP on asexual maturation and gametocyte formation of Plasmodium falciparum grown in vitro was examined over a wide range of concentrations. Cyclic AMP inhibited both processesExpand
Characterization of the gene encoding the largest subunit of Plasmodium falciparum RNA polymerase III.
TLDR
The isolation, sequence analysis, structure, and expression of the gene encoding the largest subunit of RNA polymerase III (RPIII) from Plasmodium falciparum is reported, and noteworthy amino acid sequences and structures were identified. Expand
Isolation and characterization of a chaperonin-60 gene of the human malaria parasite Plasmodium falciparum.
TLDR
The isolation and sequence of genomic clones encoding a chaperonin 60 gene from the human malaria parasite Plasmodium falciparum are reported, revealing good identity with other chaper onin 60 proteins. Expand
Studies of colicin E1 plasmid functions by analysis of deletions and TnA insertions of the plasmid
  • J. Inselburg
  • Biology, Medicine
  • Journal of bacteriology
  • 1 October 1977
TLDR
A strong correlation has been observed between the ability of colicin E1 plasmid deoxyribonucleic acid to be relaxed and the ability to be transferred by conjugation. Expand
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