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Chemical Approaches to the Synthesis of Peptides and Proteins
Introduction Amino Acids and Peptide and Protein Structure Amino Acid Activation and Coupling Protection Schemes for Peptide Synthesis The Synthesis of Peptides Solid-Phase Peptide Synthesis The… Expand
ChemMatrix, a poly(ethylene glycol)-based support for the solid-phase synthesis of complex peptides.
- F. García-Martín, Martina Quintanar-Audelo, +6 authors F. Albericio
- Chemistry, Medicine
- Journal of combinatorial chemistry
- 21 February 2006
CM (ChemMatrix) resin is a new, totally poly(ethylene glycol) (PEG)-based resin, made exclusively from primary ether bonds and, therefore, highly chemically stable, and performs excellently for the preparation of hydrophobic, highly structured, and poly-Arg peptides, as compared to polystyrene (PS) resins. Expand
Microalgae of different phyla display antioxidant, metal chelating and acetylcholinesterase inhibitory activities
Abstract Methanol and hexane extracts from Tetraselmis chuii, Nannochloropsis oculata, Chlorella minutissima and Rhodomonas salina were evaluated for total phenolic contents, radical scavenging… Expand
Preparation and application of the 5-(4-(9-fluorenylmethyloxycarbonyl)aminomethyl-3,5-dimethoxyphenoxy)-valeric acid (PAL) handle for the solid-phase synthesis of C-terminal peptide amides under mild…
The pure para isomer of title compound (I) was prepared by each of two efficient five-step routes, in overall yields from 52% to 74%. The handle I was coupled into a variety of amino group-containing… Expand
Polymers and drug delivery systems.
Polymeric systems of drug carriers are of high interest because they are an appropriate tool for time- and distribution-controlled drug delivery, and the mechanisms involved in controlled release require polymers with a variety of physicochemical properties. Expand
Thiopeptide Antibiotics: Retrospective and Recent Advances
Regardless of their limited solubility, intensive investigations are bringing thiopeptide derivatives closer to the clinic, where they are likely to show their veritable therapeutic potential. Expand
On the use of PyAOP, a phosphonium salt derived from HOAt, in solid-phase peptide synthesis
Abstract Phosphonium derivatives of HOAt such as PyAOP are useful for the solid-phase preparation of a range of peptides that include those incorporating hindered amino acids, difficult short… Expand
Fatty acid composition and biological activities of Isochrysis galbana T-ISO, Tetraselmis sp. and Scenedesmus sp.: possible application in the pharmaceutical and functional food industries
Results suggest that these microalgae, particularly I. galbana T-ISO, could be a source of biomolecules for the pharmaceutical industry and the production of functional food ingredients and can be considered as an advantageous alternative to several currently producedmicroalgae. Expand
Fatty acid profile of different species of algae of the Cystoseira genus: a nutraceutical perspective
- Catarina Vizetto-Duarte, H. Pereira, +5 authors J. Varela
- Biology, Medicine
- Natural product research
- 2 January 2015
The fatty acid composition of six macroalgae from the Cystoseira genus stood out for their low PUFA/saturated fatty acid, low n-6PUFA/n-3 PUFA ratios as well as favourable unsaturation, atherogenicity and thrombogenicity indices, suggesting a high nutritional value with potential applications in the nutraceutical industry. Expand
Occurrence and Minimization of Cysteine Racemization during Stepwise Solid-Phase Peptide Synthesis(1)(,)(2).
The levels of racemization in the model peptide were in the entirely unacceptable range of 5-33%. Expand