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low-density lipoprotein receptor-related protein 2, human

Known as: gp330, Low Density Lipoprotein Receptor-Related Protein 2, low density lipoprotein receptor-related protein 2, human 
Low-density lipoprotein receptor-related protein 2 (4655 aa, ~200 kDa) is encoded by the human LRP2 gene. This protein plays a role in receptor… 
National Institutes of Health

Related topics

Related topics

12 relations
Cholesterol HomeostasisEGF-Like DomainHedgehog Signaling PathwayIntegral Membrane Proteins

Broader (1)

LDL-Receptor Related Protein 2

Papers overview

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Highly Cited
2011
Highly Cited
2011
Megalin/LRP2 Expression Is Induced by Peroxisome Proliferator-Activated Receptor -Alpha and -Gamma: Implications for PPARs' Roles in Renal Function
Background Megalin is a large endocytic receptor with relevant functions during development and adult life. It is expressed at… 
2007
2007
Genetic association of low-density lipoprotein receptor-related protein 2 (LRP2) with plasma lipid levels.
AIM Not all genetic factors predisposing phenotypic features of dyslipidemia have been identified. We studied the association… 
Highly Cited
2006
Highly Cited
2006
The Hemopexin and O-Glycosylated Domains Tune Gelatinase B/MMP-9 Bioavailability via Inhibition and Binding to Cargo Receptors*
Gelatinase B/matrix metalloproteinase-9 (MMP-9), a key regulator and effector of immunity, contains a C-terminal hemopexin domain… 
Highly Cited
2000
Highly Cited
2000
Clearance of amyloid β-peptide from brain: transport or metabolism?
We read with interest the article by Iwata et al.1 in the February 2000 issue of Nature Medicine suggesting a major degrading… 
Highly Cited
2000
Highly Cited
2000
Role of Megalin (gp330) in Transcytosis of Thyroglobulin by Thyroid Cells
When thyroglobulin (Tg) is endocytosed by thyrocytes and transported to lysosomes, thyroid hormones (T4 and T3) are released… 
Highly Cited
1995
Highly Cited
1995
Glycoprotein 330/Low Density Lipoprotein Receptor-related Protein-2 Mediates Endocytosis of Low Density Lipoproteins via Interaction with Apolipoprotein B100 (*)
The ability of glycoprotein 330/low density lipoprotein receptor-related protein-2 (LRP-2) to function as a lipoprotein receptor… 
Highly Cited
1991
Highly Cited
1991
Primary structure of alpha 2-macroglobulin receptor-associated protein. Human homologue of a Heymann nephritis antigen.
Highly Cited
1986
Highly Cited
1986
Ultrastructural localization by monoclonal antibodies of brush border antigens expressed by glomeruli. II. Extrarenal distribution.
An immunoultrastructural study has been undertaken for analysis of the extrarenal localization of two brush border (BB… 
Highly Cited
1986
Highly Cited
1986
Ultrastructural localization by monoclonal antibodies of brush border antigens expressed by glomeruli. I. Renal distribution.
The authors have previously reported the production of monoclonal anti-brush border antibodies defining two glycoprotein (gp… 
Highly Cited
1985
Highly Cited
1985
Antibody-induced redistribution of Heymann antigen on the surface of cultured glomerular visceral epithelial cells: possible role in the pathogenesis of Heymann glomerulonephritis.
In this study we analyze the ability of antibodies that produce passive Heymann glomerulonephritis to induce antigen… 
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