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low-density lipoprotein receptor-related protein 2, human

Known as: gp330, Low Density Lipoprotein Receptor-Related Protein 2, low density lipoprotein receptor-related protein 2, human 
Low-density lipoprotein receptor-related protein 2 (4655 aa, ~200 kDa) is encoded by the human LRP2 gene. This protein plays a role in receptor… 
National Institutes of Health

Related topics

Related topics

12 relations
Cholesterol HomeostasisEGF-Like DomainHedgehog Signaling PathwayIntegral Membrane Proteins

Broader (1)

LDL-Receptor Related Protein 2

Papers overview

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Highly Cited
2006
Highly Cited
2006
The Hemopexin and O-Glycosylated Domains Tune Gelatinase B/MMP-9 Bioavailability via Inhibition and Binding to Cargo Receptors*
Gelatinase B/matrix metalloproteinase-9 (MMP-9), a key regulator and effector of immunity, contains a C-terminal hemopexin domain… 
Highly Cited
2005
Highly Cited
2005
Megalin binds and mediates cellular internalization of folate binding protein
Folate is an essential vitamin involved in a number of biological processes. High affinity folate binding proteins (FBPs) exist… 
Highly Cited
2002
Highly Cited
2002
Megalin Functions as an Endocytic Sonic Hedgehog Receptor*
Embryos deficient in the morphogen Sonic hedgehog (Shh) or the endocytic receptor megalin exhibit common neurodevelopmental… 
Highly Cited
1998
Highly Cited
1998
Megalin is an endocytic receptor for insulin.
Renal clearance is a major pathway for regulating the levels of insulin and other low molecular weight polypeptide hormones in… 
Highly Cited
1997
Highly Cited
1997
Interaction of apolipoprotein J-amyloid beta-peptide complex with low density lipoprotein receptor-related protein-2/megalin. A mechanism to prevent pathological accumulation of amyloid beta-peptide.
Apolipoprotein J (apoJ) has been shown to be the predominant amyloid beta-peptide (Abeta)-binding protein in cerebrospinal fluid… 
Highly Cited
1995
Highly Cited
1995
Glycoprotein 330/Low Density Lipoprotein Receptor-related Protein-2 Mediates Endocytosis of Low Density Lipoproteins via Interaction with Apolipoprotein B100 (*)
The ability of glycoprotein 330/low density lipoprotein receptor-related protein-2 (LRP-2) to function as a lipoprotein receptor… 
Highly Cited
1992
Highly Cited
1992
Low density lipoprotein receptor-related protein and gp330 bind similar ligands, including plasminogen activator-inhibitor complexes and lactoferrin, an inhibitor of chylomicron remnant clearance.
Highly Cited
1991
Highly Cited
1991
Primary structure of alpha 2-macroglobulin receptor-associated protein. Human homologue of a Heymann nephritis antigen.
Highly Cited
1986
Highly Cited
1986
Ultrastructural localization by monoclonal antibodies of brush border antigens expressed by glomeruli. II. Extrarenal distribution.
An immunoultrastructural study has been undertaken for analysis of the extrarenal localization of two brush border (BB… 
Highly Cited
1985
Highly Cited
1985
Antibody-induced redistribution of Heymann antigen on the surface of cultured glomerular visceral epithelial cells: possible role in the pathogenesis of Heymann glomerulonephritis.
In this study we analyze the ability of antibodies that produce passive Heymann glomerulonephritis to induce antigen… 
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