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Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines
TLDR
The MISEV2018 guidelines include tables and outlines of suggested protocols and steps to follow to document specific EV-associated functional activities, and a checklist is provided with summaries of key points. Expand
Mesenchymal stem cell-derived microvesicles protect against acute tubular injury.
TLDR
It is found that microvesicles derived from human bone marrow MSCs stimulated proliferation in vitro and conferred resistance of tubular epithelial cells to apoptosis, suggesting RNA-dependent biologic effects. Expand
Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity,
TLDR
This review encompasses the most important advances in liver functions and hepatotoxicity and analyzes which mechanisms can be studied in vitro and how closely hepatoma, stem cell and iPS cell–derived hepatocyte-like-cells resemble real hepatocytes. Expand
Vesiclepedia: A Compendium for Extracellular Vesicles with Continuous Community Annotation
TLDR
Vesiclepedia is a community-annotated compendium of molecular data on extracellular vesicles that aims to provide a single authoritative source for information on vesicle structure and function. Expand
Endothelial progenitor cell derived microvesicles activate an angiogenic program in endothelial cells by a horizontal transfer of mRNA.
TLDR
Protein expression and functional studies showed that PI3K and eNOS play a critical role in the angiogenic effect of MVs, suggesting that EPCs may activate angiogenesis in endothelial cells by releasing MVs able to trigger an angiogens program. Expand
Exosomes/microvesicles as a mechanism of cell-to-cell communication.
TLDR
The transfer of gene products from injured cells may explain stem cell functional and phenotypic changes without the need of transdifferentiation into tissue cells, and the evidence supporting a bidirectional exchange of genetic information between stem and injured cells is discussed. Expand
Applying extracellular vesicles based therapeutics in clinical trials – an ISEV position paper
TLDR
In this position statement, basic and clinical scientists, as members of the International Society for Extracellular Vesicles (ISEV) and of the European Cooperation in Science and Technology (COST) program, summarize recent developments and the current knowledge of EV-based therapies. Expand
Identification of a tumor‐initiating stem cell population in human renal carcinomas
TLDR
It is demonstrated that CD105+ cells and clones derived from renal carcinomas were enriched in tumor‐initiating cells with stem characteristics, suggesting the capability of tumor‐ initiating stem cells to in vivo differentiate also in endothelial cells. Expand
Microvesicles released from human renal cancer stem cells stimulate angiogenesis and formation of lung premetastatic niche.
TLDR
This work reports that a subset of tumor-initiating cells expressing the mesenchymal stem cell marker CD105 in human renal cell carcinoma releases MVs that trigger angiogenesis and promote the formation of a premetastatic niche. Expand
Isolation and Characterization of a Stem Cell Population from Adult Human Liver
TLDR
A pluripotent progenitor population in adult human liver that could provide a basis for cell therapy strategies is identified and characterized by stringent conditions of liver cell cultures. Expand
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