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losigame

Known as: (5RS)-(alphaSR)-5-(2-chlorophenylhydroxymethyl)-4-methoxy-2(5H)-furanone, 5-(2-chlorophenylhydroxymethyl)-4-methoxy-2-(5H)-furanone, Losigamone 
National Institutes of Health

Related topics

Related topics

2 relations

Narrower (1)

A 033

Broader (1)

Furans

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2013
Review
2013
Molecular mechanisms of antiseizure drug activity at GABAA receptors
Review
2005
Review
2005
Voltage gated ion channels: targets for anticonvulsant drugs.
Epilepsy is one of the most prevalent neurological syndromes in the world today. Epilepsy describes a group of brain disorders… 
Highly Cited
2004
Highly Cited
2004
Pharmacological and electrographic properties of epileptiform activity induced by elevated K2+ and lowered Ca2+ and Mg2+ concentration in rat hippocampal slices
We studied some of the physiological and pharmacological properties of an in vitro model of epileptic seizures induced by… 
Review
2000
Review
2000
Clinical pharmacology of new antiepileptic drugs.
Advances in neurobiology, molecular biology, and pharmaceutical science have led to the development of a number of new… 
Review
1999
Review
1999
Progress report on new antiepileptic drugs: a summary of the fourth Eilat conference (EILAT IV)
Highly Cited
1999
Highly Cited
1999
Preclinical evaluation of newly approved and potential antiepileptic drugs against cocaine-induced seizures.
Seizures and status epilepticus are among the neurological complications of cocaine overdose in humans. The aim of the present… 
Review
1996
Review
1996
The Clinical Pharmacokinetics of the Newer Antiepileptic Drugs
SummaryFollowing the introduction of felbamate, gabapentin, lamotrigine, oxcarbazepine and vigabatrin in the early 1990s, other… 
Highly Cited
1995
Highly Cited
1995
The effects of D-23129, a new experimental anticonvulsant drug, on neurotransmitter amino acids in the rat hippocampus in vitro
1995
1995
Effects of the Anticonvulsant Losigamone and Its Isomers on the GABAA Receptor System
Summary: We conducted in vitro studies to clarify the possible involvement of GABA, receptor‐mediated processes in the… 
Highly Cited
1995
Highly Cited
1995
The effects of anticonvulsant agents on 4-aminopyridine induced epileptiform activity in rat hippocampus in vitro
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