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lonafarnib

Known as: 1-Piperidinecarboxamide, 4(2-(4-(11R-3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo(5,6)cyclohepta(1,2-b)pyridine-11-yl)-1-piperidinyl)-2-oxoethyl)-, 4-[2-[4-(3,10-Dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-1-piperidinyl]-2-oxoethyl]-1-piperidinecarboxamide, 4-[2-[4-[(11R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl]-1-piperidinyl]-2-oxoethyl]-1-piperidinecarboxamide 
A synthetic tricyclic derivative of carboxamide with antineoplastic properties. Lonarfanib binds to and inhibits farnesyl transferase, an enzyme… Expand
National Institutes of Health

Papers overview

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Highly Cited
2018
Highly Cited
2018
Importance Hutchinson-Gilford progeria syndrome (HGPS) is an extremely rare fatal premature aging disease. There is no approved… Expand
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Highly Cited
2016
Highly Cited
2016
Background: Hutchinson-Gilford progeria syndrome is an extremely rare, fatal, segmental premature aging syndrome caused by a… Expand
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Highly Cited
2015
Highly Cited
2015
BACKGROUND Therapies for chronic hepatitis delta virus (HDV) infection are unsatisfactory. Prenylation is essential for HDV and… Expand
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Review
2015
Review
2015
The mechanisms determining persistence of hepatitis B virus (HBV) infection and long-term pathogenesis of HBV-associated liver… Expand
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Highly Cited
2013
Highly Cited
2013
  • K. Jiang
  • Nature Medicine
  • 2013
  • Corpus ID: 52867100
nature medicine volume 19 | number 5 | may 2013 515 Life is short—especially for children with Hutchinson-Gilford progeria… Expand
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Highly Cited
2012
Highly Cited
2012
Hutchinson–Gilford progeria syndrome (HGPS) is an extremely rare, fatal, segmental premature aging syndrome caused by a mutation… Expand
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Highly Cited
2005
Highly Cited
2005
Lonafarnib (SCH66336) is a farnesyl transferase inhibitor (FTI) that inhibits the post-translational lipid modification of H-Ras… Expand
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Highly Cited
2005
Highly Cited
2005
Recent studies indicate that a rare population of primitive quiescent BCR-ABL+ cells are innately insensitive to imatinib… Expand
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Highly Cited
2004
Highly Cited
2004
Purpose: To establish the maximum tolerated dose of lonafarnib, a novel farnesyltransferase inhibitor, in combination with… Expand
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Highly Cited
2002
Highly Cited
2002
The development of chronic myeloid leukemia (CML) is dependent on the deregulated tyrosine kinase of the oncoprotein BCR-ABL… Expand
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