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lonafarnib
Known as:
1-Piperidinecarboxamide, 4(2-(4-(11R-3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo(5,6)cyclohepta(1,2-b)pyridine-11-yl)-1-piperidinyl)-2-oxoethyl)-
, 4-[2-[4-(3,10-Dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-1-piperidinyl]-2-oxoethyl]-1-piperidinecarboxamide
, 4-[2-[4-[(11R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl]-1-piperidinyl]-2-oxoethyl]-1-piperidinecarboxamide
A synthetic tricyclic derivative of carboxamide with antineoplastic properties. Lonarfanib binds to and inhibits farnesyl transferase, an enzyme…
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National Institutes of Health
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Related topics
Related topics
8 relations
Broader (3)
Enzyme Inhibitors
Piperidines
Pyridines
NCIt Antineoplastic Agent Terminology
gemcitabine/lonafarnib
lonafarnib/paclitaxel/trastuzumab
Narrower (2)
Sarasar
[ LAB] SCH66336
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Review
2015
Review
2015
Hepatitis B and Delta Virus: Advances on Studies about Interactions between the Two Viruses and the Infected Hepatocyte
K. Giersch
,
M. Dandri
Journal of Clinical and Translational Hepatology
2015
Corpus ID: 8224619
The mechanisms determining persistence of hepatitis B virus (HBV) infection and long-term pathogenesis of HBV-associated liver…
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2010
2010
Computer-aided drug design and ADMET predictions for identification and evaluation of novel potential farnesyltransferase inhibitors in cancer therapy.
C. D. da Silva
,
V. D. da Silva
,
+4 authors
C. Taft
Journal of Molecular Graphics and Modelling
2010
Corpus ID: 35027142
Review
2008
Review
2008
Current available therapies and future directions in the treatment of malignant gliomas
A. Desjardins
,
D. Reardon
,
J. Vredenburgh
Biologics : targets & therapy
2008
Corpus ID: 7018427
The prognosis of patients diagnosed with malignant glioma (MG) remains poor. However, recent advances in neuro-oncology allowing…
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Highly Cited
2007
Highly Cited
2007
Phase I and pharmacokinetic study of the oral farnesyltransferase inhibitor lonafarnib administered twice daily to pediatric patients with advanced central nervous system tumors using a modified…
M. Kieran
,
R. Packer
,
+17 authors
L. Kun
Journal of Clinical Oncology
2007
Corpus ID: 11188832
PURPOSE A dose-escalation phase I and pharmacokinetic study of the farnesyltransferase inhibitor lonafarnib (SCH66336) was…
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2007
2007
Enhancement of the antitumor activity of tamoxifen and anastrozole by the farnesyltransferase inhibitor lonafarnib (SCH66336)
G. Liu
,
Cindy H. Marrinan
,
+6 authors
B. Long
Anti-Cancer Drugs
2007
Corpus ID: 7009843
Lonafarnib is an orally bioavailable farnesyltransferase inhibitor. Originally developed to block the membrane localization of…
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2006
2006
A phase I study of temozolomide (TMZ) and the farnesyltransferase inhibitor (FTI), lonafarnib (Sarazar, SCH66336) in recurrent glioblastoma.
Mark R Gilbert
,
P. Gaupp
,
+8 authors
W. Yung
Journal of Clinical Oncology
2006
Corpus ID: 20039420
1556 Background: Farnesylation is essential for the post-translational modification of several proteins that play a role in cell…
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2006
2006
Identification of unstable metabolites of Lonafarnib using liquid chromatography-quadrupole time-of-flight mass spectrometry, stable isotope incorporation and ion source temperature alteration.
W. Tong
,
S. Chowdhury
,
Ai-Duen Su
,
W. Feng
,
A. Ghosal
,
K. Alton
Journal of Mass Spectrometry
2006
Corpus ID: 23869095
Structural characterization of unstable metabolites and other drug-derived entities poses a serious challenge to the analytical…
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Review
2004
Review
2004
Farnesyltransferase inhibitors as anticancer agents: critical crossroads.
R. Doll
,
P. Kirschmeier
,
W. Bishop
Current opinion in drug discovery & development
2004
Corpus ID: 40576751
Farnesyltransferase (FT) inhibitors were originally designed as anticancer agents, and were thought to act by inhibiting the…
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2004
2004
Synthesis of 5-bromopyridyl-2-magnesium chloride and its application in the synthesis of functionalized pyridines.
Jinhua J. Song
,
N. Yee
,
Zhulin Tan
,
Jinghua Xu
,
S. Kapadia
,
C. Senanayake
Organic Letters
2004
Corpus ID: 34237611
[reaction: see text] The 5-bromopyridyl-2-magnesium chloride (2), which was not accessible previously, was efficiently…
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Highly Cited
2003
Highly Cited
2003
High-performance liquid chromatography-atmospheric pressure photoionization/tandem mass spectrometric analysis for small molecules in plasma.
Y. Hsieh
,
K. Merkle
,
Ganfeng Wang
,
J. Brisson
,
Walter A. Korfmacher
Analytical Chemistry
2003
Corpus ID: 27734435
A generic high-performance liquid chromatography (HPLC) system interfaced with an atmospheric pressure photoionization (APPI…
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