lonafarnib

Known as: 1-Piperidinecarboxamide, 4(2-(4-(11R-3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo(5,6)cyclohepta(1,2-b)pyridine-11-yl)-1-piperidinyl)-2-oxoethyl)-, 4-[2-[4-(3,10-Dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-1-piperidinyl]-2-oxoethyl]-1-piperidinecarboxamide, 4-[2-[4-[(11R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl]-1-piperidinyl]-2-oxoethyl]-1-piperidinecarboxamide 
A synthetic tricyclic derivative of carboxamide with antineoplastic properties. Lonarfanib binds to and inhibits farnesyl transferase, an enzyme… (More)
National Institutes of Health

Papers overview

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2015
2015
BACKGROUND Therapies for chronic hepatitis delta virus (HDV) infection are unsatisfactory. Prenylation is essential for HDV and… (More)
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2011
2011
Farnesyl transferase inhibitors (FTIs) inhibit the farnesylation of proteins, including RAS and RHEB (Ras homolog enriched in… (More)
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2008
2008
Although an activating mutation of Ras is commonly observed in myelodysplastic syndrome (MDS), the role of Ras in the natural… (More)
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Highly Cited
2005
Highly Cited
2005
Farnesyl transferase (FT) inhibitors (FTI) are anticancer agents developed to target oncogenic Ras proteins by inhibiting Ras… (More)
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2005
2005
Recent studies indicate that a rare population of primitive quiescent BCR-ABL+ cells are innately insensitive to imatinib… (More)
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Highly Cited
2005
Highly Cited
2005
Lonafarnib (SCH66336) is a farnesyl transferase inhibitor (FTI) that inhibits the post-translational lipid modification of H-Ras… (More)
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2005
2005
PURPOSE Protein farnesylation by farnesyltransferase (FTase) is required for membrane localization and effective signal… (More)
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2004
2004
PURPOSE To establish the maximum tolerated dose of lonafarnib, a novel farnesyltransferase inhibitor, in combination with… (More)
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Highly Cited
2002
Highly Cited
2002
The development of chronic myeloid leukemia (CML) is dependent on the deregulated tyrosine kinase of the oncoprotein BCR-ABL… (More)
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