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lonafarnib

Known as: 1-Piperidinecarboxamide, 4(2-(4-(11R-3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo(5,6)cyclohepta(1,2-b)pyridine-11-yl)-1-piperidinyl)-2-oxoethyl)-, 4-[2-[4-(3,10-Dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-1-piperidinyl]-2-oxoethyl]-1-piperidinecarboxamide, 4-[2-[4-[(11R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl]-1-piperidinyl]-2-oxoethyl]-1-piperidinecarboxamide 
A synthetic tricyclic derivative of carboxamide with antineoplastic properties. Lonarfanib binds to and inhibits farnesyl transferase, an enzyme… 
National Institutes of Health

Related topics

Related topics

8 relations

Broader (3)

Enzyme InhibitorsPiperidinesPyridines
NCIt Antineoplastic Agent Terminologygemcitabine/lonafarniblonafarnib/paclitaxel/trastuzumab

Narrower (2)

Sarasar[ LAB] SCH66336

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
Effect of the farnesyl transferase inhibitor lonafarnib on sensitivity of melanoma cells to the multikinase inhibitor sorafenib and on Rheb farnesylation and mTOR signaling.
9077 Background: Farnesyl transferase inhibitors (FTIs) inhibit the post-translational farnesylation of a number of target… 
Review
2015
Review
2015
Hepatitis B and Delta Virus: Advances on Studies about Interactions between the Two Viruses and the Infected Hepatocyte
The mechanisms determining persistence of hepatitis B virus (HBV) infection and long-term pathogenesis of HBV-associated liver… 
Review
2008
Review
2008
Current available therapies and future directions in the treatment of malignant gliomas
The prognosis of patients diagnosed with malignant glioma (MG) remains poor. However, recent advances in neuro-oncology allowing… 
2007
2007
Enhancement of the antitumor activity of tamoxifen and anastrozole by the farnesyltransferase inhibitor lonafarnib (SCH66336)
Lonafarnib is an orally bioavailable farnesyltransferase inhibitor. Originally developed to block the membrane localization of… 
2006
2006
A phase I study of temozolomide (TMZ) and the farnesyltransferase inhibitor (FTI), lonafarnib (Sarazar, SCH66336) in recurrent glioblastoma.
1556 Background: Farnesylation is essential for the post-translational modification of several proteins that play a role in cell… 
2006
2006
Identification of unstable metabolites of Lonafarnib using liquid chromatography-quadrupole time-of-flight mass spectrometry, stable isotope incorporation and ion source temperature alteration.
Structural characterization of unstable metabolites and other drug-derived entities poses a serious challenge to the analytical… 
2005
2005
Mutations in the BRAF and N-ras genes in childhood acute lymphoblastic leukaemia
selected cell line models, suppression of Ras signaling or the farnesylated Rho-B proteins promotes heterotypic adhesion through… 
Review
2004
Review
2004
Farnesyltransferase inhibitors as anticancer agents: critical crossroads.
Farnesyltransferase (FT) inhibitors were originally designed as anticancer agents, and were thought to act by inhibiting the… 
2004
2004
Synthesis of 5-bromopyridyl-2-magnesium chloride and its application in the synthesis of functionalized pyridines.
[reaction: see text] The 5-bromopyridyl-2-magnesium chloride (2), which was not accessible previously, was efficiently… 
Highly Cited
2003
Highly Cited
2003
High-performance liquid chromatography-atmospheric pressure photoionization/tandem mass spectrometric analysis for small molecules in plasma.
A generic high-performance liquid chromatography (HPLC) system interfaced with an atmospheric pressure photoionization (APPI… 
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