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Overcoming barriers to green chemistry in the pharmaceutical industry – the Green Aspiration Level™ concept
“Green chemistry” refers to the promotion of safe, sustainable, and waste-minimizing chemical processes. The proliferation of green chemistry metrics without any clear consensus on industry standards
A superior method for the reduction of secondary phosphine oxides.
TLDR
DIBAL-H and triisobutylaluminum hydride have been found to be outstanding reductants for secondary phosphine oxides (SPOs), and many SPOs can now be reduced at cryogenic temperatures, and conditions for preservation of reducible functional groups have be found.
Organometallic methods for the synthesis and functionalization of azaindoles.
TLDR
In this tutorial review, a survey of the recent development of organometallic chemistry-based methods for azaindole synthesis is surveyed.
Activation of TMSCN by N-heterocyclic carbenes for facile cyanosilylation of carbonyl compounds.
TLDR
N-Heterocyclic carbenes were found to be highly effective organocatalysts in activating TMSCN for facile cyanosilylation of carbonyl compounds and tolerate various functional groups.
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