C. Senanayake

Publications412
h-index47
Citations7,665
Highly Influential Citations30
Claim Author Page
Author pages are created from data sourced from our academic publisher partnerships and public sources.

Recommended Authors

  • Heewon Lee
  • 143 Publications, 2,273 Citations
  • J. Song
  • 140 Publications, 2,298 Citations
  • S. L. Buchwald
  • 987 Publications, 61,700 Citations
  • N. Grinberg
  • 142 Publications, 1,650 Citations
  • Publications
  • Influence
Rapid access to enantiopure bupropion and its major metabolite by stereospecific nucleophilic substitution on an α-ketotriflate
Abstract A stereospecific method for the synthesis of enantiopure α-aminoketone from its corresponding α-hydroxy-ketone via the triflate intermediate is discussed. This strategy provides a rapid and… Expand
  • 76
  • 3
A superior method for the reduction of secondary phosphine oxides.
[reaction: see text] Diisobutylaluminum hydride (DIBAL-H) and triisobutylaluminum have been found to be outstanding reductants for secondary phosphine oxides (SPOs). All classes of SPOs can be… Expand
  • 86
  • 2
An improved method of amide synthesis using acyl chlorides
A simple, mild and highly efficient condition for amide synthesis from acyl chlorides has been developed to minimize hydrolysis, racemization and other side reactions. This method should expand… Expand
  • 46
  • 2
Overcoming barriers to green chemistry in the pharmaceutical industry – the Green Aspiration Level™ concept
TLDR
We propose the Green Aspiration Level™ (GAL) concept as a novel process performance metric that quantifies the environmental impact of producing a specific pharmaceutical agent while taking into account the complexity of the ideal synthetic process for producing the target molecule. Expand
  • 131
  • 2
  • PDF
Chiral mandelic acid template provides a highly practical solution for (S)-oxybutynin synthesis.
  • 57
  • 1
Biological actions of formoterol isomers.
Racemic beta(2) agonists, composed of equal amounts of (R)- and (S)-isomers, can display anomalous actions that compromise their effectiveness as asthma therapies. Loss of efficacy during regular use… Expand
  • 48
  • 1
Activation of TMSCN by N-heterocyclic carbenes for facile cyanosilylation of carbonyl compounds.
N-Heterocyclic carbenes were found to be highly effective organocatalysts in activating TMSCN for facile cyanosilylation of carbonyl compounds. Cyano transfer from TMSCN to aldehydes and ketones… Expand
  • 148
  • 1
Vibrational circular dichroism of amylose carbamate: structure and solvent-induced conformational changes
The conformational changes of amylose tris-(dimethylphenylcarbamate) (ADMPC) in the presence of polar solvents were investigated by VCD spectroscopy for the first time. The conformation of ADMPC was… Expand
  • 35
  • 1
Chromatographic and spectroscopic studies on the chiral recognition of sulfated beta-cyclodextrin as chiral mobile phase additive enantiomeric separation of a chiral amine.
A fast enantiomeric separation of a chiral aromatic amine was achieved, using ultra high pressure liquid chromatography and highly sulfated beta-cyclodextrin (S-beta-CD) as a chiral additive in the… Expand
  • 43
  • 1
Efficient synthesis of Empagliflozin, an inhibitor of SGLT-2, utilizing an AlCl3-promoted silane reduction of a β-glycopyranoside.
An efficient production synthesis of the SGLT-2 inhibitor Empagliflozin (5) from acid 1 is described. The key tactical stage involves I/Mg exchange of aryl iodide 2 followed by addition to glucono… Expand
  • 38
  • 1