Share This Author
Mechanistic studies on the chiral recognition of polysaccharide-based chiral stationary phases using liquid chromatography and vibrational circular dichroism: reversal of elution order of…
Organometallic methods for the synthesis and functionalization of azaindoles.
- Jinhua J. Song, J. Reeves, F. Gallou, Zhulin Tan, N. Yee, C. Senanayake
- ChemistryChemical Society reviews
- 18 June 2007
In this tutorial review, a survey of the recent development of organometallic chemistry-based methods for azaindole synthesis is surveyed.
Activation of TMSCN by N-heterocyclic carbenes for facile cyanosilylation of carbonyl compounds.
- Jinhua J. Song, F. Gallou, J. Reeves, Zhulin Tan, N. Yee, C. Senanayake
- ChemistryThe Journal of organic chemistry
- 4 January 2006
N-Heterocyclic carbenes were found to be highly effective organocatalysts in activating TMSCN for facile cyanosilylation of carbonyl compounds and tolerate various functional groups.
Chromatographic and spectroscopic studies on the chiral recognition of sulfated beta-cyclodextrin as chiral mobile phase additive enantiomeric separation of a chiral amine.
Vibrational circular dichroism of amylose carbamate: structure and solvent-induced conformational changes
Efficient synthesis of Empagliflozin, an inhibitor of SGLT-2, utilizing an AlCl3-promoted silane reduction of a β-glycopyranoside.
An efficient production synthesis of the SGLT-2 inhibitor Empagliflozin from acid 1 is described and the process was implemented for production on a metric ton scale for commercial launch.
Insights into chromatographic enantiomeric separation of allenes on cellulose carbamate stationary phase.
Efficient Iron‐Catalyzed Kumada Cross‐Coupling Reactions Utilizing Flow Technology under Low Catalyst Loadings
An efficient continuous flow iron-catalyzed Kumada cross-coupling was developed for the coupling of 2-chloropyrazine and various aryl Grignard reagents in presence of low catalyst loadings (0.5…
A Practical Asymmetric Synthesis of Isopropyl (1R,2S)-Dehydrocoronamate
A novel asymmetric synthesis of isopropyl (1R,2S)-dehydrocoronamate is described from (S)-1,2,4-butanetriol as the starting material in 28% overall yield. Highlights of this synthetic route include…
Formation of 2-Trifluoromethylphenyl Grignard Reagent via Magnesium−Halogen Exchange: Process Safety Evaluation and Concentration Effect
The thermal stability profile for a solution of 2-trifluoromethylphenyl magnesium chloride at 1.5 M concentration in THF was determined using an Advanced Reactive System Screening Tool (ARSST). The…