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[ LAB] SCH66336

Known as: SCH-66336, SCH66336, SCH 66336 
 
National Institutes of Health

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Highly Cited
2006
Highly Cited
2006
In this study, we have characterized a panel of NSCLC cell lines with differential sensitivity to gefitinib for activating… Expand
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2005
2005
The identification of signaling pathways critical to myeloma growth and progression has yielded an array of novel agents with… Expand
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2005
2005
In this study, the feasibility and activity of combined chemotherapy of the farnesyl transferase inhibitor SCH66336 and… Expand
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Highly Cited
2004
Highly Cited
2004
Ras farnesyltransferase inhibitor (FTI) exhibit antiproliferative and antiangiogenic effects through a mechanism that is poorly… Expand
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Highly Cited
2002
Highly Cited
2002
The development of chronic myeloid leukemia (CML) is dependent on the deregulated tyrosine kinase of the oncoprotein BCR-ABL… Expand
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Highly Cited
2001
Highly Cited
2001
The Philadelphia (Ph) chromosome is found in approximately 3% of pediatric patients with acute lymphoblastic leukemia (ALL) and… Expand
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Highly Cited
2001
Highly Cited
2001
BCR/ABL, the oncoprotein responsible for chronic myeloid leukemia (CML), transforms hematopoietic cells through both Ras… Expand
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Highly Cited
2000
Highly Cited
2000
Farnesyl protein transferase (FT), an enzyme that catalyzes the first step in the posttranslational modification of ras and a… Expand
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Highly Cited
2000
Highly Cited
2000
Farnesyltransferase inhibitors (FTIs) were developed to target abnormal signaling pathways that are commonly activated in… Expand
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Highly Cited
1998
Highly Cited
1998
We have been developing a series of nonpeptidic, small molecule farnesyl protein transferase inhibitors that share a common… Expand
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