[ LAB] SCH66336

Known as: SCH-66336, SCH66336, SCH 66336 
 
National Institutes of Health

Topic mentions per year

Topic mentions per year

1998-2016
024619982016

Papers overview

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Highly Cited
2006
Highly Cited
2006
In this study, we have characterized a panel of NSCLC cell lines with differential sensitivity to gefitinib for activating… (More)
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Highly Cited
2005
Highly Cited
2005
Lonafarnib (SCH66336) is a farnesyl transferase inhibitor (FTI) that inhibits the post-translational lipid modification of H-Ras… (More)
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2005
2005
BACKGROUND The farnesyltransferase inhibitor SCH66336, in combination with other receptor tyrosine kinase inhibitors, inhibits… (More)
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2003
2003
The constitutive activity of a number of growth and cell survival pathways are thought to contribute to the inherent resistance… (More)
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Highly Cited
2002
Highly Cited
2002
The development of chronic myeloid leukemia (CML) is dependent on the deregulated tyrosine kinase of the oncoprotein BCR-ABL… (More)
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Highly Cited
2001
Highly Cited
2001
BCR/ABL, the oncoprotein responsible for chronic myeloid leukemia (CML), transforms hematopoietic cells through both Ras… (More)
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2001
2001
Previous studies have demonstrated that astrocytomas express elevated levels of activated Ras.GTP despite the absence of… (More)
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2001
2001
The Philadelphia (Ph) chromosome is found in approximately 3% of pediatric patients with acute lymphoblastic leukemia (ALL) and… (More)
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Highly Cited
2000
Highly Cited
2000
Farnesyl protein transferase (FT), an enzyme that catalyzes the first step in the posttranslational modification of ras and a… (More)
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2000
2000
Purpose: SCH66336 is an orally active, farnesyl protein transferase inhibitor. SCH66336 inhibits ras farnesylation in tumor cells… (More)
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