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lomefloxacin

Known as: LFLX, Lomefloxacinum, (+-)-1-Ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid 
A synthetic broad-spectrum fluoroquinolone with antibacterial activity. Lomefloxacin inhibits DNA gyrase, a type II topoisomerase involved in the… 
National Institutes of Health

Related topics

Related topics

21 relations

Broader (4)

Anti-Bacterial AgentsFluoroquinolonesQuinolone Antibacterial AgentsTopoisomerase II Inhibitors
BronchitisDrug AllergyEscherichia coli InfectionsKlebsiella Infections

Narrower (5)

DecalogifloxMaxaquinNY 198Okacin

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2005
Highly Cited
2005
The simultaneous separation and determination of five quinolone antibiotics using isocratic reversed-phase HPLC: application to stability studies on an ofloxacin tablet formulation.
Highly Cited
2004
Highly Cited
2004
Photostability of sunscreen products influences the efficiency of protection with regard to UV‐induced genotoxic or photoageing‐related endpoints
Background  Acute as well as chronic sun exposure induces biologically damaging effects in skin including photoageing and cancer… 
2003
2003
Fluorescence spectroscopy determination of fluoroquinolones by charge-transfer reaction.
Highly Cited
2000
Highly Cited
2000
Determination of quinolones in plasma samples by capillary electrophoresis using solid-phase extraction.
Highly Cited
2000
Highly Cited
2000
Ciprofloxacin, Lomefloxacin, or Levofloxacin as Treatment for Chronic Osteomyelitis
ABSTRACT The efficacy and safety of three oral fluoroquinolones (lomefloxacin, levofloxacin, and ciprofloxacin) for the treatment… 
Highly Cited
1998
Highly Cited
1998
Photocleavage of DNA by the fluoroquinolone antibacterials.
Highly Cited
1997
Highly Cited
1997
Photogeneration of Fluoride by the Fluoroquinolone Antimicrobial Agents Lomefloxacin and Fleroxacin
The photolysis (> 320 nm) of the fluoroquinolone antibacterial agents lomefloxacin and fleroxacin results in the loss of their F3… 
Highly Cited
1997
Highly Cited
1997
Quinolone Antibiotic Photodynamic Production of 8‐Oxo‐7,8‐dihydro‐2‘‐deoxyguanosine in Cultured Liver Epithelial Cells
To study the basis for the phototoxicity of quinolones, a class of synthetic antibacterials, the photodynamic ability to mediate… 
Highly Cited
1988
Highly Cited
1988
In vitro activity of lomefloxacin, a new quinolone antimicrobial agent, in comparison with those of other agents
The in vitro activity of lomefloxacin (SC-47111; NY-198), a new difluorinated quinolone, was compared with those of ofloxacin… 
Highly Cited
1988
Highly Cited
1988
Pharmacokinetics and tolerance of lomefloxacin after sequentially increasing oral doses
The pharmacokinetics of five dose levels of lomefloxacin (100, 200, 400, 600, and 800 mg) were examined in a single-dose, double… 
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