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lochnericine

National Institutes of Health

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Indole Alkaloids

Papers overview

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2015
2015
Engineering overexpression of ORCA3 and strictosidine glucosidase in Catharanthus roseus hairy roots increases alkaloid production
Catharanthus roseus produces many pharmaceutically important terpenoid indole alkaloids (TIAs) such as vinblastine, vincristine… 
2012
2012
Regulation of vinblastine biosynthesis in cell suspension cultures of catharanthus roseus
Various elicitors of hydroxylase, peroxidase, acetyltransferase and inhibitors of oxygenase were added to a Catharanthus roseus… 
2011
2011
1 A STEREOSELECTIVE HYDROXYLATION STEP OF ALKALOID BIOSYNTHESIS BY A UNIQUE CYTOCHROME P 450 IN CATHARANTHUS ROSEUS
A STEREOSELECTIVE HYDROXYLATION STEP OF ALKALOID BIOSYNTHESIS BY A UNIQUE CYTOCHROME P450 IN CATHARANTHUS ROSEUS* Lesley-Ann… 
2005
2005
Transient effects of overexpressing anthranilate synthase alpha and beta subunits in Catharanthus roseus hairy roots.
Catharanthus roseus produces two economically valuable anticancer drugs, vinblastine and vincristine. These drugs are members of… 
Highly Cited
2003
Highly Cited
2003
Jasmonate-induced epoxidation of tabersonine by a cytochrome P-450 in hairy root cultures of Catharanthus roseus.
2003
2003
Role of the Non‐Mevalonate Pathway in Indole Alkaloid Production by Catharanthus roseus Hairy Roots
The 1‐deoxy‐d‐xylulose‐5‐phosphate (DXP) pathway (non‐mevalonate pathway) leading to terpenoids via isopentenyl diphosphate (IPP… 
1999
1999
Inhibitor studies of tabersonine metabolism in C. roseus hairy roots.
1998
1998
Transient studies of light-adapted cultures of hairy roots of Catharanthus roseus: growth and indole alkaloid accumulation.
Cultures of C. roseus transgenic ("hairy") root clones LBE-6-1 and LBE-4-2 were adapted with periodic daily illumination to… 
1976
1976
Catharanthus alkaloids XXXII: isolation of alkaloids from Catharanthus trichophyllus roots and structure elucidation of cathaphylline.
Further examination of the cytotoxic alkaloid fractions of Catharanthus trichophyllus roots afforded nine alkaloids. Two of these… 
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