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Folliculin encoded by the BHD gene interacts with a binding protein, FNIP1, and AMPK, and is involved in AMPK and mTOR signaling
TLDR
The data suggest that FLCN, mutated in Birt–Hogg–Dubé syndrome, and its interacting partner FNIP1 may be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. Expand
Purpureocillium, a new genus for the medically important Paecilomyces lilacinus.
TLDR
Comparing clinical isolates with strains isolated from soil, insects and nematodes using 18S rRNA gene, internal transcribed spacer (ITS) and partial translation elongation factor 1-α sequences shows that P. lilacinus is not related to Paecilomyces, and the ITS and TEF sequences of the Purpureocillium lilacinum isolates used for biocontrol of nematode pests are identical to those causing infections in humans. Expand
Polyphasic taxonomy of Aspergillus fumigatus and related species.
The variability within Aspergillus fumigatus Fresenius and related species was examined using macro-, micro-morphology, growth temperature regimes and extrolite patterns. In addition, DNA analysesExpand
Kidney-targeted Birt-Hogg-Dube gene inactivation in a mouse model: Erk1/2 and Akt-mTOR activation, cell hyperproliferation, and polycystic kidneys.
TLDR
The conditional BHD knockout mouse may be a useful research model for dissecting multistep kidney carcinogenesis, and rapamycin may be considered as a potential treatment for Birt-Hogg-Dubé syndrome. Expand
Niabella aurantiaca gen. nov., sp. nov., isolated from a greenhouse soil in Korea.
  • B. Kim, H. Weon, +4 authors S. Go
  • Biology, Medicine
  • International journal of systematic and…
  • 1 March 2007
TLDR
On the basis of the polyphasic evidence from this study, strain R2A15-11(T) represents a novel genus and species, for which the name Niabella aurantiaca gen. nov., sp. Expand
Homozygous loss of BHD causes early embryonic lethality and kidney tumor development with activation of mTORC1 and mTORC2
TLDR
A role for PI3K-AKT pathway activation in kidney tumor formation caused by loss of BHD is supported and inhibitors of both m TORC1 and mTORC2 may be effective as potential therapeutic agents for BHD-associated kidney cancer. Expand
Ectopic Expression of the Catalytic Subunit of Telomerase Protects against Brain Injury Resulting from Ischemia and NMDA-Induced Neurotoxicity
TLDR
Evidence is provided that TERT is inducible in postmitotic neurons after ischemic brain injury and prevents NMDA neurotoxicity through shift of the cytosolic free Ca2+ into the mitochondria, and thus plays a protective role in ameliorating isChemic neuronal cell death. Expand
A re-consideration of Pseudoperonospora cubensis and P. humuli based on molecular and morphological data.
TLDR
The phylogenetic analyses of P. cubensis and P. humuli showed that they share a high level of sequence homology; the morphology of the sporangiophores, sporangia, and dehiscence apparatus confirmed the similarity of the two species, and they are reduced to the status of a taxonomic synonym. Expand
Effect of Humidification and Hardening Treatment on Seed Germination of Rice
To find out the effects of humidification and hardening of rice (Oryza sativa L. cv. Ilpumbyeo) seeds on the germination, both normal and artificially aged seeds with 60% germination rate wereExpand
ASPERGILLUS LUCHUENSIS , AN INDUSTRIALLY IMPORTANT BLACK ASPERGILLUS IN EAST ASIA
TLDR
Extrolite analysis of strains of A. luchuensis showed that they do not produce mycotoxins and therefore can be considered safe for food and beverage fermentations, and the species is probably common in the fermentation environment of East Asia. Expand
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