Author pages are created from data sourced from our academic publisher partnerships and public sources.
- Publications
- Influence
An alternative route to cyclic terpenes by reductive cyclization in iridoid biosynthesis
- F. Geu-Flores, Nathaniel H. Sherden, +6 authors S. O’Connor
- Biology, Medicine
- Nature
- 6 December 2012
The iridoids comprise a large family of distinctive bicyclic monoterpenes that possess a wide range of pharmacological activities, including anticancer, anti-inflammatory, antifungal and… Expand
Chemistry and Biology of Monoterpene Indole Alkaloid Biosynthesis
- S. O’Connor, Justin J. Maresh
- Chemistry
- 17 October 2006
Development of Transcriptomic Resources for Interrogating the Biosynthesis of Monoterpene Indole Alkaloids in Medicinal Plant Species
- Elsa Góngora-Castillo, K. Childs, +12 authors C. Buell
- Biology, Medicine
- PloS one
- 26 December 2012
The natural diversity of plant metabolism has long been a source for human medicines. One group of plant-derived compounds, the monoterpene indole alkaloids (MIAs), includes well-documented… Expand
A virus-induced gene silencing approach to understanding alkaloid metabolism in Catharanthus roseus.
- D. Liscombe, S. O’Connor
- Biology, Medicine
- Phytochemistry
- 1 November 2011
The anticancer agents vinblastine and vincristine are bisindole alkaloids derived from coupling vindoline and catharanthine, monoterpenoid indole alkaloids produced exclusively by the Madagascar… Expand
Antibody Humanization Using Monovalent Phage Display*
- M. Baca, L. Presta, S. O’Connor, J. Wells
- Biology, Medicine
- The Journal of Biological Chemistry
- 18 April 1997
Antibody humanization often requires the replacement of key residues in the framework regions with corresponding residues from the parent non-human antibody. These changes are in addition to grafting… Expand
Homolog of tocopherol C methyltransferases catalyzes N methylation in anticancer alkaloid biosynthesis
- D. Liscombe, A. Usera, S. O’Connor
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 18 October 2010
Madagascar periwinkle (Catharanthus roseus) is the sole source of the anticancer drugs vinblastine and vincristine, bisindole alkaloids derived from the dimerization of the terpenoid indole alkaloids… Expand
Genome-guided investigation of plant natural product biosynthesis.
- Franziska Kellner, Jeongwoon Kim, +10 authors S. O’Connor
- Biology, Medicine
- The Plant journal : for cell and molecular…
- 1 May 2015
The medicinal plant Madagascar periwinkle, Catharanthus roseus (L.) G. Don, produces hundreds of biologically active monoterpene-derived indole alkaloid (MIA) metabolites and is the sole source of… Expand
The bHLH transcription factor BIS1 controls the iridoid branch of the monoterpenoid indole alkaloid pathway in Catharanthus roseus
- Alex Van Moerkercke, P. Steensma, +13 authors A. Goossens
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 15 June 2015
Significance Terpenoids are the largest group of plant-specialized metabolites and include many valuable bioactive compounds, such as the blockbuster anticancer drugs vincristine and vinblastine,… Expand
Chemistry and biology of monoterpene indole alkaloid biosynthesis.
- S. O’Connor, Justin J. Maresh
- Chemistry, Medicine
- Natural product reports
- 25 July 2006
Covering: up to 2006
Monoterpene indole alkaloids exhibit a diverse array of structures and biological activities. The biosynthetic pathways for several representative terpene indole alkaloids are… Expand
Standards for plant synthetic biology: a common syntax for exchange of DNA parts.
- N. Patron, D. Orzáez, +55 authors Jim Haseloff
- Biology, Medicine
- The New phytologist
- 1 October 2015
Inventors in the field of mechanical and electronic engineering can access multitudes of components and, thanks to standardization, parts from different manufacturers can be used in combination with… Expand