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An alternative route to cyclic terpenes by reductive cyclization in iridoid biosynthesis
The iridoids comprise a large family of distinctive bicyclic monoterpenes that possess a wide range of pharmacological activities, including anticancer, anti-inflammatory, antifungal andExpand
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Development of Transcriptomic Resources for Interrogating the Biosynthesis of Monoterpene Indole Alkaloids in Medicinal Plant Species
The natural diversity of plant metabolism has long been a source for human medicines. One group of plant-derived compounds, the monoterpene indole alkaloids (MIAs), includes well-documentedExpand
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A virus-induced gene silencing approach to understanding alkaloid metabolism in Catharanthus roseus.
The anticancer agents vinblastine and vincristine are bisindole alkaloids derived from coupling vindoline and catharanthine, monoterpenoid indole alkaloids produced exclusively by the MadagascarExpand
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Antibody Humanization Using Monovalent Phage Display*
Antibody humanization often requires the replacement of key residues in the framework regions with corresponding residues from the parent non-human antibody. These changes are in addition to graftingExpand
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Homolog of tocopherol C methyltransferases catalyzes N methylation in anticancer alkaloid biosynthesis
Madagascar periwinkle (Catharanthus roseus) is the sole source of the anticancer drugs vinblastine and vincristine, bisindole alkaloids derived from the dimerization of the terpenoid indole alkaloidsExpand
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Genome-guided investigation of plant natural product biosynthesis.
The medicinal plant Madagascar periwinkle, Catharanthus roseus (L.) G. Don, produces hundreds of biologically active monoterpene-derived indole alkaloid (MIA) metabolites and is the sole source ofExpand
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The bHLH transcription factor BIS1 controls the iridoid branch of the monoterpenoid indole alkaloid pathway in Catharanthus roseus
Significance Terpenoids are the largest group of plant-specialized metabolites and include many valuable bioactive compounds, such as the blockbuster anticancer drugs vincristine and vinblastine,Expand
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Chemistry and biology of monoterpene indole alkaloid biosynthesis.
Covering: up to 2006 Monoterpene indole alkaloids exhibit a diverse array of structures and biological activities. The biosynthetic pathways for several representative terpene indole alkaloids areExpand
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Standards for plant synthetic biology: a common syntax for exchange of DNA parts.
Inventors in the field of mechanical and electronic engineering can access multitudes of components and, thanks to standardization, parts from different manufacturers can be used in combination withExpand
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