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Discovery of betulinic acid as a selective inhibitor of human melanoma that functions by induction of apoptosis
As a result of bioassay–guided fractionation, betulinic acid, a pentacyclic triterpene, was identified as a melanoma–specific cytotoxic agent and antitumour activity was mediated by the induction of apoptosis. Expand
Cucurbitacins and cucurbitane glycosides: structures and biological activities.
The natural cucurbitacins constitute a group of triterpenoid substances which are well-known for their bitterness and toxicity and are divided into twelve categories. Expand
Dictionary of alkaloids
Each entry in the Dictionary covers the following range of data, where appropriate: nomenclature molecular formula and molecular weight structure diagrams stereoisomers and derivatives physical properties occurrence biological properties bibliography. Expand
Cytotoxic and antimalarial alkaloids from the bulbs of Crinum amabile.
A new alkaloid (-)-amabiline was isolated from the bulbs of Crinum amabile (Amaryllidaceae), and alkaloids 2, 4, and 5 were found to be the principal cytotoxic and antimalarial constituents. Expand
A direct bioautographic tlc assay for compounds possessing antibacterial activity.
A simple bioassay for the direct detection of antibacterial compounds on tlc plates has been developed. A series of natural products and different stationary phases were tested in order to establishExpand
Liquid chromatography-electrospray ionization mass spectrometry study of the flavonoids of the roots of Astragalus mongholicus and A. membranaceus.
This is the first report of flavonoid glycoside malonates in these two Astragalus species, and malonate 2 is a structurally completely identified new compound. Expand
Silvestrol and episilvestrol, potential anticancer rocaglate derivatives from Aglaia silvestris.
Two cytotoxic rocaglate derivatives possessing an unusual dioxanyloxy unit, silvestrol (1) and episilvestrol (2), were isolated from the fruits and twigs of Aglaia silvestris by bioassay-guidedExpand
Natural product drug discovery and development: new perspectives on international collaboration.
A discussion of policies for international collaboration and compensation being implemented by several developed country organizations, and the perspectives on the current developments given by representatives of some of the source countries located in the regions of greatest biodiversity. Expand
Nigranoic acid, a triterpenoid from Schisandra sphaerandra that inhibits HIV-1 reverse transcriptase.
Nigranoic acid showed activity in several anti-HIV reverse transcriptase and polymerase assays and its structure elucidation and unambiguous NMR spectral assignment were achieved by the combination of 1D- and 2D-NMR techniques with the aid of computer modeling. Expand