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Strictosidine activation in Apocynaceae: towards a "nuclear time bomb"?
BackgroundThe first two enzymatic steps of monoterpene indole alkaloid (MIA) biosynthetic pathway are catalysed by strictosidine synthase (STR) that condensates tryptamine and secologanin to formExpand
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Characterization of the plastidial geraniol synthase from Madagascar periwinkle which initiates the monoterpenoid branch of the alkaloid pathway in internal phloem associated parenchyma.
Madagascar periwinkle (Catharanthus roseus [L.] G. Don, Apocynaceae) produces monoterpene indole alkaloids (MIAs), secondary metabolites of high interest due to their therapeutic value. A key step inExpand
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The subcellular organization of strictosidine biosynthesis in Catharanthus roseus epidermis highlights several trans‐tonoplast translocations of intermediate metabolites
Catharanthus roseus synthesizes a wide range of valuable monoterpene indole alkaloids, some of which have recently been recognized as functioning in plant defence mechanisms. More specifically, inExpand
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Jasmonate-induced epoxidation of tabersonine by a cytochrome P-450 in hairy root cultures of Catharanthus roseus.
Methyl jasmonate, a chemical inducer of secondary metabolism, was shown to promote tabersonine 2 biosynthesis in hairy root cultures of Catharanthus roseus. Tabersonine 6,7-epoxidase activity wasExpand
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Cellular and sub-cellular organisation of the monoterpenoid indole alkaloid pathway in Catharanthus roseus
The Madagascar periwinkle (Catharanthus roseus) monoterpene indole alkaloids (MIAs), either as (hetero)dimers (vinblastine, vincristine) or as monomers (ajmalicine) are valuable pharmaceuticals withExpand
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Notch receptors, partners and regulators: from conserved domains to powerful functions.
The Notch gene was first identified in Drosophila as a locus required for development of many structures (Poulson 1937). The diversity of biological processes regulated by Notch in Drosophila and itsExpand
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A single gene encodes isopentenyl diphosphate isomerase isoforms targeted to plastids, mitochondria and peroxisomes in Catharanthus roseus
Isopentenyl diphosphate isomerases (IDI) catalyze the interconversion of the two isoprenoid universal C5 units, isopentenyl diphosphate and dimethylally diphosphate, to allow the biosynthesis of theExpand
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Spatial organization of the vindoline biosynthetic pathway in Catharanthus roseus.
Vindoline constitutes the main terpenoid indole alkaloid accumulated in leaves of Catharanthus roseus, and four genes involved in its biosynthesis have been identified. However, the spatialExpand
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Molecular and biochemical analysis of a Madagascar periwinkle root-specific minovincinine-19-hydroxy-O-acetyltransferase.
The terminal steps in the biosynthesis of the monoterpenoid indole alkaloids vindoline and minovincinine are catalyzed by separate acetyl coenzyme A-dependent O-acetyltransferases in MadagascarExpand
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Chapter Nine Evolution of acyltransferase genes: Origin and diversification fo the BAHD superfamily of acyltransferases involved in secondary metabolism
Enzymatic acylation is a widespread substitution reaction that is notably involved in the diversification of natural substances produced by plant secondary metabolism. Acylation may also triggerExpand
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