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lobucavir

Known as: C-Oxetanocin-G, 9-((1R,2R,3S)-2,3-Bis(hydroxymethyl)cyclobutyl)guanine, 2-amino-9-(2,3-bis(hydroxymethyl)cyclobutyl)-1,9-dihydro-6H-purin-6-one 
A nucleoside analog of deoxyguanine with broad-spectrum antiviral activity. Lobucavir is phosphorylated in vivo to its triphosphate form and inhibits… 
National Institutes of Health

Related topics

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9 relations

Narrower (2)

Abbott 69992BMS 180194

Broader (6)

Anti-HIV AgentsAntiviral AgentsEnzyme InhibitorsGuanine
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2007
2007
Stereoselective route to oxetanocin carbocyclic analogues based on a [2 + 2] photocycloaddition to a chiral 2(5H)-furanone.
The synthesis of the trisubstituted cyclobutane 7, which is a suitable precursor for the preparation of oxetanocin carbocyclic… 
2000
2000
Ribavirin and mycophenolic acid potentiate the activity of guanine- and diaminopurine-based nucleoside analogues against hepatitis B virus.
Review
1999
Review
1999
THERAPY WITH NUCLEOSIDE ANALOGUES FOR HEPATITIS B VIRUS INFECTION
1993
1993
Synthesis and antiviral activity of carbocyclic oxetanocin analogues (C-OXT-A, C-OXT-G) and related compounds. II.
9-(cis-3-Hydroxymethyl-2-methylenecyclobutyl)guanine (3b) and 9-(3-methylene-trans-2-hydroxymethylcyclobutyl)guanine (4b) were… 
Highly Cited
1992
Highly Cited
1992
Synthesis and anti-HIV activity of 9-[c-4,t-5-bis(hydroxymethyl)cyclopent-2-en-r-1-yl]-9H-adenine.
The synthesis and in vitro anti-HIV activity of two new racemic nucleoside analogues are described; namely, 9-[c-4,t-5-bis… 
1992
1992
Inhibition of intrahepatic hepatitis B virus replication by antiviral drugs in a novel transgenic mouse model
Transgenic mice which carry the integrated human hepatitis B virus (HBV) genome and produce HBV particles in the liver were… 
1991
1991
Evaluation of SQ 34,514: pharmacokinetics and efficacy in experimental herpesvirus infections in mice
The new antiviral nucleoside SQ 34,514 [(1R-1 alpha, 2 beta, 3 alpha)-2-amino-9- [2,3-bis(hydroxymethyl)cyclobutyl]-6H-purin-6… 
Highly Cited
1990
Highly Cited
1990
Cyclobut-A and cyclobut-G: broad-spectrum antiviral agents with potential utility for the therapy of AIDS.
Given the complex involvement of herpesviruses in the pathogenesis of AIDS, an agent capable of controlling the replication of… 
Highly Cited
1990
Highly Cited
1990
Cyclobut-A and cyclobut-G, carbocyclic oxetanocin analogs that inhibit the replication of human immunodeficiency virus in T cells and monocytes and macrophages in vitro
Two newly synthesized carbocyclic oxetanocin analogs, (+/-)-9-[(1 beta,2 alpha,3 beta)-2,3-bis(hydroxymethyl)-1-cyclobutyl… 
1989
1989
Anti-herpesvirus activity of carbocyclic oxetanocin G in vitro.
A series of new compounds, carbocyclic oxetanocins, have been synthesized and their anti-herpesvirus activity determined… 
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