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Mapping of herpes simplex virus-1 neurovirulence to gamma 134.5, a gene nonessential for growth in culture.
Inasmuch as the product of the gamma 134.5 gene extended the host range of the virus by enabling it to replicate and destroy brain cells, it is a viral neurovirulence factor.
Virucidal activity of polysaccharide extracts from four algal species against herpes simplex virus.
National Institutes of Health consensus development conference statement: Management of hepatitis B
Questions remain about which groups of patients benefit from therapy and at which point in the course of disease this therapy should be initiated, and limited rigorous evidence exists demonstrating the effect of these therapies on important long-term clinical outcomes, such as the development of hepatocellular carcinoma or a reduction in deaths.
In Vitro Activities of Benzimidazole d- and l-Ribonucleosides against Herpesviruses
Results demonstrate that the benzimidazole ribonucleosides are active against human CMV and EBV and suggest that they may be useful for the treatment of infections caused by these herpesviruses.
Human Cytomegalovirus UL97 Kinase Is Required for the Normal Intranuclear Distribution of pp65 and Virion Morphogenesis
It is proposed that the kinase plays an important role in the acquisition of tegument during virion morphogenesis in the nucleus and that this activity represents an important step in the production of mature virus particles.
The natural history of recurrent herpes simplex labialis: implications for antiviral therapy.
- S. Spruance, J. Overall, E. Kern, G. Krueger, V. Pliam, W. Miller
- MedicineThe New England journal of medicine
- 14 July 1977
Pain, lesion size, mean virus titers from lesion swabs, and frequency of virus-positive lesions were maximal during the first 24 hours and decreased thereafter, and maximum lesion virus titer after the first visit.
Antiviral activities of biflavonoids.
The results indicated that robustaflavone exhibited strong inhibitory effects against influenza A and influenza B viruses with EC50 values of 2.0 micrograms/ml and 0.2 microgram/ml, respectively, and selectivity index values (SI) of 16 and 454, respectively.
Human Cytomegalovirus UL97 Kinase Activity Is Required for the Hyperphosphorylation of Retinoblastoma Protein and Inhibits the Formation of Nuclear Aggresomes
It is concluded that both UL97 kinase activity and the LxCxE RB binding motif are required for the phosphorylation and stabilization of RB in infected cells and that this effect can be antagonized by the antiviral drug maribavir.
Genital herpes in guinea pigs: pathogenesis of the primary infection and description of recurrent disease.
- L. Stanberry, E. Kern, J. Richards, T. Abbott, J. Overall
- Medicine, BiologyThe Journal of infectious diseases
- 1 September 1982
Genital infection in the guinea pig shares many features with genital herpes in humans and provides a model to explore mechanisms of latency and reactivation and to evaluate several methods for control of recurrent disease.
Dendrimers, a New Class of Candidate Topical Microbicides with Activity against Herpes Simplex Virus Infection
- N. Bourne, L. Stanberry, E. Kern, G. Holan, B. Matthews, D. Bernstein
- BiologyAntimicrobial Agents and Chemotherapy
- 1 September 2000
Three dendrimers evaluated for in vitro activity against genital HSV infection in mice significantly reduced infection rates when 15 μl of a 100-mg/ml solution was administered immediately prior to intravaginal challenge, and the most effective compound, BRI-2999, provided significant protection even when applied 30 min before challenge, the first report of microbicidal activity by dendricers in vivo.