Skip to search formSkip to main contentSkip to account menu

lanosterol synthase activity

Known as: (S)-2,3-epoxysqualene mutase (cyclizing, lanosterol-forming), 2,3-epoxysqualene lanosterol cyclase activity, oxidosqualene:lanosterol cyclase activity 
Catalysis of the reaction: (S)-2,3-epoxysqualene = lanosterol. This is a cyclization reaction that forms the sterol nucleus. [EC:5.4.99.7, RHEA:14624… 
National Institutes of Health

Related topics

Related topics

2 relations
LSS geneLanosterol synthase

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2013
2013
Molecular characterization and differential expression studies of an oxidosqualene cyclase (OSC) gene of Brahmi (Bacopa monniera)
Triterpenoid saponins are the class of secondary metabolites, synthesized via isoprenoid pathway. Oxidosqualene cyclases (OSCs… 
2012
2012
Lanosterol biosynthesis: the critical role of the methyl-29 group of 2,3-oxidosqualene for the correct folding of this substrate and for the construction of the five-membered D ring.
Lanosterol synthase catalyzes the polycyclization reaction of (3S)-2,3-oxidosqualene (1) into tetracyclic lanosterol 2 by folding… 
2009
2009
Cloning and Functional Analysis of a beta-amyrin synthase gene associated with oleanolic acid biosynthesis in Gentiana straminea MAXIM.
Phytosterols and triterpenes are synthesized by oxidosqualene cyclases (OSCs) via the isoprenoid pathway. Here, GsAS1--a full… 
2004
2004
Umbelliferone aminoalkyl derivatives, a new class of squalene-hopene cyclase inhibitors.
2002
2002
Potent apoptotic effects of saponins from Liliaceae plants in L1210 cells
We isolated eight saponins, a hexacyclic lanosterol tetraglycoside (1), a 27‐norlanosterol tetraglycoside (2) and six spirostanol… 
2002
2002
Evidence for multiple sterol methyl transferase pathways in Pneumocystis carinii
The sterol composition of Pneumocystis carinii, an opportunistic pathogen responsible for life-threatening pneumonia in… 
1997
1997
Synthesis and inhibition studies of sulfur-substituted squalene oxide analogues as mechanism-based inhibitors of 2,3-oxidosqualene-lanosterol cyclase.
The synthesis and biological evaluation of three new sulfur-substituted oxidosqualene (OS) analogues (1-3) are presented. In… 
1996
1996
Mechanistic and Metabolic Studies of Sterol 24,25-Double Bond Reduction in Manduca sexta
Larvae of Manduca sexta were used to obtain a cell-free sterol 24,25-reductase. From the midgut of fifth instar larvae fed a… 
1980
1980
A deficiency of mixed function oxidase activities in the cholesterol biosynthetic pathway of human granulocytes.
Highly purified human granulocytes synthesize [14C]farnesol and [14C]squalene but not [14C]sterols from [14C]mevalonic acid… 
Highly Cited
1969
Highly Cited
1969
Steroid metabolism in the human foeto-placental unit.
The concept of a fetoplacental unit as a steroid-synthesizing unit was elaborated by perfusing the previable fetus and placenta… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)