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Picrosides I and II, selective enhancers of the mitogen-activated protein kinase-dependent signaling pathway in the action of neuritogenic substances on PC12D cells.
TLDR
Results suggest that picrosides I and II enhance bFGF-, staurosporine- or dbcAMP-induced neurite outgrowth from PC12D cells, probably by amplifying a down-stream step of MAP kinase in the intracellularMAP kinase-dependent signaling pathway.
Nardosinone, a novel enhancer of nerve growth factor in neurite outgrowth from PC12D cells
TLDR
The results suggest that nardosinone enhances the NGF-induced neurite outgrowth from PC12D cells probably by amplifying an up-stream step of MAPK kinase in the N GF receptor-mediated intracellular signaling pathway.
A monogalactosyl diacylglycerol from a cultured marine dinoflagellate, Scrippsiella trochoidea.
A novel monogalactosyl diacylglycerol [1] has been isolated from a cultured marine dinoflagellate Scrippsiella trochoidea, and its structure was elucidated by spectroscopic methods
Potentiation of nerve growth factor-action by picrosides I and II, natural iridoids, in PC12D cells.
TLDR
The results suggest that picroside I or II enhances NGF-induced neurite outgrowth from PC12D cells, probably by amplifying a down-stream step of MAP kinase in the NGF receptor-mediated intracellularMAP kinase-dependent signaling pathway.
[Goniodomin A induces modulation of actomyosin ATPase activity mediated through conformational change of actin].
TLDR
The results suggest that goniodomin A affects actin directly to modify the actin-myosin interaction and that gonodomin A-induced activation of the actomyosin ATPase activity may be physiologically significant because its activation is sensitive to the regulatory protein system, troponin-tropomyOSin complex.
Imperanene, a novel phenolic compound with platelet aggregation inhibitory activity from Imperata cylindrica.
TLDR
Imperanene, a novel phenolic compound isolated from Imperata cylindrica, showed platelet aggregation inhibitory activity and its structure was elucidated by spectroscopic evidence.
Nardosinone enhances nerve growth factor-induced neurite outgrowth in a mitogen-activated protein kinase- and protein kinase C-dependent manner in PC12D cells.
TLDR
The results suggest that the enhancement of NGF-induced neurite outgrowth from PC12D cells by nardosinone involves activation of a down-stream step of the MAP kinase-dependent cascade of N GF coupled with PKC.
Nardosinone, the first enhancer of neurite outgrowth-promoting activity of staurosporine and dibutyryl cyclic AMP in PC12D cells.
TLDR
Nardosinone is the first enhancer of the neuritogenic action of dbcAMP and staurosporine and may become a useful pharmacological tool for studying the mechanism of action of not only NGF but also both the neur itogenic substances.
Halenaquinone, a novel phosphatidylinositol 3-kinase inhibitor from a marine sponge, induces apoptosis in PC12 cells.
TLDR
It is suggested that halenaquinone causes the death of PC12 cells through an apoptotic process and that the mechanism of halenquinone-induced apoptosis may be partially explained by the inhibition of phosphatidylinositol 3-kinase activity.
The combination of rat mast cell and rabbit aortic smooth muscle is the simple bioassay for the screening of anti-allergic ingredient from methanolic extract of Corydalis tuber.
TLDR
Combination of rat mast cells and rabbit aorta is good bioassay to search the anti-allergic ingredient, and effective fractions from Corydalis tuber are obtained using this assay.
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