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Osteoclast-derived exosomal miR-214-3p inhibits osteoblastic bone formation
TLDR
The results suggest that osteoclast-derived exosomal miR-214-3p transfers to osteoblasts to inhibit bone formation, which may be a strategy for treating skeletal disorders involving a reduction in bone formation. Expand
Analysis of triterpenoids in Ganoderma lucidum using liquid chromatography coupled with electrospray ionization mass spectrometry
TLDR
Fragmentations and regularities in fragmentation pathways were reported for the first time, and were implemented for the analysis of triterpenoids in G. lucidum. Expand
Cytotoxic triterpenoids from Ganoderma lucidum.
TLDR
A systematic study of the metabolites in Ganoderma lucidum led to isolation of 43 triterpenoids, six of them of which are hitherto unknown, and their structure-activity relationships are discussed. Expand
Microbial transformation of ginsenoside Rb1 by Acremonium strictum
TLDR
It is demonstrated that microbial culture parallels mammalian metabolism; therefore, A. strictum might be a useful tool for generating mammalian metabolites of related analogs of ginsenosides for complete structural identification and for further use in pharmaceutical research in this series of compounds. Expand
Phytochemical analysis of traditional Chinese medicine using liquid chromatography coupled with mass spectrometry.
TLDR
High-performance liquid chromatography coupled with multistage mass spectrometry (HPLC-MS(n) technique was still proved to be a rapid and sensitive method to analyze the majority of the many constituents in herbal medicines, particularly for the detection of those present in minor or trace amounts. Expand
Characterization of phenolic compounds in the fruits of Forsythia suspensa by high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry.
TLDR
These fragmentation rules were implemented to analyze phenolic compounds in the fruits of F. suspensa, and the fragmentation behaviors of furofuran lignans displayed a typical cleavage of the tetrahydrofuran ring. Expand
A green protocol for efficient discovery of novel natural compounds: characterization of new ginsenosides from the stems and leaves of Panax ginseng as a case study.
TLDR
The established 2D LC/LTQ-Orbitrap-MS/NMR approach outperforms the conventional approaches in respect of significantly improved efficiency, much less use of drug materials and organic solvent. Expand
The quest for modernisation of traditional Chinese medicine
TLDR
This narrative review aims to summarise the findings of the FP7 GP-TCM project, highlight the scientific evidence behind TCM, update the most important milestones and pitfalls, and propose integrity, integration and innovation as key principles for further modernisation of TCM. Expand
Quantitative determination of six major triterpenoids in Ganoderma lucidum and related species by high performance liquid chromatography.
TLDR
The results indicated that the developed reversed-phase liquid chromatographic method could be readily utilized as a quality control method for G. lucidum and related species. Expand
Sterol utilization and metabolism by Heliothis zea
TLDR
The novel sterol specificities observed in this study appear to be associated with the dual role of sterols as membrane inserts (nonmetabolic) and as precursors to the ecdysteroids (metabolic). Expand
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