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Anti-obesity effect of Nelumbo nucifera leaves extract in mice and rats.
- Y. Ono, E. Hattori, Yukitaka Fukaya, S. Imai, Y. Ohizumi
- Biology, Medicine
- Journal of ethnopharmacology
- 30 June 2006
The leaf of Nelumbo nucifera Gaertn. (family Nymphaeaceae) has been used for summer heat syndrome as home remedy in Japan and China, and it has recently been used to treat obesity in China. So we… Expand
Nobiletin and its related flavonoids with CRE-dependent transcription-stimulating and neuritegenic activities.
- H. Nagase, Naoki Omae, +7 authors Y. Ohizumi
- Biology, Medicine
- Biochemical and biophysical research…
- 2 December 2005
cAMP response element (CRE) transcription is dysregulated in neurodegenerative disorders in the central nervous system (CNS), including polyglutamine diseases. As the first step to find natural… Expand
Nobiletin, a Citrus Flavonoid, Improves Memory Impairment and Aβ Pathology in a Transgenic Mouse Model of Alzheimer's Disease
- H. Onozuka, A. Nakajima, +9 authors Y. Ohizumi
- Journal of Pharmacology and Experimental…
- 1 September 2008
Increasing evidence suggests that the elevation of β-amyloid (Aβ) peptides in the brain is central to the pathogenesis of Alzheimer's disease (AD). Our recent studies have demonstrated that… Expand
Inhibitions of histamine release and prostaglandin E2 synthesis by mangosteen, a Thai medicinal plant.
- K. Nakatani, M. Atsumi, +4 authors Y. Ohizumi
- Biological & pharmaceutical bulletin
- 1 September 2002
The fruit hull of mangosteen, Garcinia mangostana L. has been used as a Thai indigenous medicine for many years. However, its mechanism of action as a medicine has not been elucidated. The present… Expand
Inhibition of cyclooxygenase and prostaglandin E2 synthesis by gamma-mangostin, a xanthone derivative in mangosteen, in C6 rat glioma cells.
- K. Nakatani, N. Nakahata, T. Arakawa, H. Yasuda, Y. Ohizumi
- Biology, Medicine
- Biochemical pharmacology
The fruit hull of mangosteen, Garcinia mangostana L., has been used for many years as a medicine for treatment of skin infection, wounds, and diarrhea in Southeast Asia. In the present study, we… Expand
Pharmacological properties of alpha-mangostin, a novel histamine H1 receptor antagonist.
- N. Chairungsrilerd, K. Furukawa, T. Ohta, S. Nozoe, Y. Ohizumi
- European journal of pharmacology
In the isolated rabbit thoracic aorta and guinea-pig trachea, alpha-mangostin inhibited histamine-induced contractions in a concentration-dependent manner in the presence or absence of cimetidine, a… Expand
Pharmacological properties of α-mangostin, a novel histamine H1 receptor antagonist
Abstract In the isolated rabbit thoracic aorta and guinea-pig trachea, α-mangostin inhibited histamine-induced contractions in a concentration-dependent manner in the presence or absence of… Expand
Uncaria rhynchophylla, a Chinese medicinal herb, has potent antiaggregation effects on Alzheimer's β‐amyloid proteins
- H. Fujiwara, K. Iwasaki, +12 authors H. Arai
- Chemistry, Medicine
- Journal of neuroscience research
- 1 August 2006
Because the deposition of β‐amyloid protein (Aβ) is a consistent pathological hallmark of Alzheimer's disease (AD) brains, inhibition of Aβ generation, prevention of Aβ fibril formation, or… Expand
Nobiletin treatment improves motor and cognitive deficits seen in MPTP-induced Parkinson model mice
Nobiletin, a polymethoxylated flavonoid found in citrus fruit peel, reportedly improves memory impairment in rodent models. Here we report its effect on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine… Expand
Palytoxin in two species of xanthid crab from the Philippines
Two species of xanthid crab, Lophozozymus pictor and Demania alcalai, known to cause fatal poisoning when ingested, were collected on southern Negros, Philippines. They were highly fatal by mouse… Expand