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ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- M. Hammerschlag, C. Dykstra, D. Vandewiele
- Computer ScienceAntimicrobial Agents and Chemotherapy
- 1 January 2007
The introduction should supply sufficient background information to allow the reader to understand and evaluate the results of the present study without referring to previous publications on the topic.
Systematic analysis of yeast strains with possible defects in lipid metabolism
A group of five European laboratories established methods suitable to screen for novel genes of the yeast Saccharomyces cerevisiae involved in lipid metabolism, regulation of lipid biosynthesis and the role of lipids in organellar membranes, and found evidence suggesting a possible role in cholesterol metabolism.
Subcellular localization of oxidosqualene cyclases from Arabidopsis thaliana, Trypanosoma cruzi, and Pneumocystis carinii expressed in yeast
Computer analysis supports the hypothesis of the structural difference since OSC from S. cerevisiae, A. thaliana, and T. carinii differ in some structural features critical for the interaction with the surface of lipid particles.
Characterization and partial purification of squalene-2,3-oxide cyclase from Saccharomyces cerevisiae.
Yeast Oxidosqualene Cyclase (Erg7p) Is a Major Component of Lipid Particles*
Evidence is provided that lipid particles are not only a depot for neutral lipids, but also participate in coordinate sterol metabolism and trafficking and serve as a storage site for compounds that may negatively affect membrane integrity.
In vitro inhibition of animal and higher plants 2,3-oxidosqualene-sterol cyclases by 2-aza-2,3-dihydrosqualene and derivatives, and by other ammonium-containing molecules.
Conversion of squalene to the pentacarbocyclic hopene.
Characterization of a mutation that results in independence of oxidosqualene cyclase (Erg7) activity from the downstream 3-ketoreductase (Erg27) in the yeast ergosterol biosynthetic pathway.
The transformation of 10α-cucurbita-5,24-dien-3β-ol into cucurbitacin C by seedlings of Cucumis sativus
Characterizing Sterol Defect Suppressors Uncovers a Novel Transcriptional Signaling Pathway Regulating Zymosterol Biosynthesis*
It is demonstrated that the expression of the ERG25/26/27 genes required for zymosterol biosynthesis are coordinately transcriptionally regulated, along with ERG1 and ERG7, in response to blocks in sterl biosynthesis.