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ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
TLDR
The introduction should supply sufficient background information to allow the reader to understand and evaluate the results of the present study without referring to previous publications on the topic.
Systematic analysis of yeast strains with possible defects in lipid metabolism
TLDR
A group of five European laboratories established methods suitable to screen for novel genes of the yeast Saccharomyces cerevisiae involved in lipid metabolism, regulation of lipid biosynthesis and the role of lipids in organellar membranes, and found evidence suggesting a possible role in cholesterol metabolism.
Subcellular localization of oxidosqualene cyclases from Arabidopsis thaliana, Trypanosoma cruzi, and Pneumocystis carinii expressed in yeast
TLDR
Computer analysis supports the hypothesis of the structural difference since OSC from S. cerevisiae, A. thaliana, and T. carinii differ in some structural features critical for the interaction with the surface of lipid particles.
Yeast Oxidosqualene Cyclase (Erg7p) Is a Major Component of Lipid Particles*
TLDR
Evidence is provided that lipid particles are not only a depot for neutral lipids, but also participate in coordinate sterol metabolism and trafficking and serve as a storage site for compounds that may negatively affect membrane integrity.
Characterizing Sterol Defect Suppressors Uncovers a Novel Transcriptional Signaling Pathway Regulating Zymosterol Biosynthesis*
TLDR
It is demonstrated that the expression of the ERG25/26/27 genes required for zymosterol biosynthesis are coordinately transcriptionally regulated, along with ERG1 and ERG7, in response to blocks in sterl biosynthesis.
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