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Malondialdehyde alteration of low density lipoproteins leads to cholesteryl ester accumulation in human monocyte-macrophages.
TLDR
It is hypothesize that one modification of LDL in vivo may result from malondialdehyde which is released from blood platelets or is produced by lipid peroxidation at the site of arterial injury.
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Function-Structure Studies and Identification of Three Enzyme Domains Involved in the Catalytic Activity in Rat Hepatic Squalene Synthase*
TLDR
Rat hepatic squalene synthase contains three conserved sections that are essential for the two reactions catalyzed by RSS, and results indicate that Section C, in particular Phe288, may be involved in the second step of catalysis.
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IDH1 gene transcription is sterol regulated and activated by SREBP-1a and SREBP-2 in human hepatoma HepG2 cells: evidence that IDH1 may regulate lipogenesis in hepatic cells.
TLDR
Results indicate that IDH1 activity is coordinately regulated with the cholesterol and fatty acid biosynthetic pathways and suggest that it is the source for the cytosolic NADPH required by these pathways.
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Differential binding of proteins to peroxisomes in rat hepatoma cells: unique association of enzymes involved in isoprenoid metabolism.
TLDR
Indirect immunofluorescence and immunoelectron microscopic techniques show that FPPS is localized predominantly in the peroxisomes of rat hepatoma H35 cells and other enzymes in the isoprenoid biosynthetic pathways, involved in the formation of FPP, are differentially associated with peroxISomes and may easily diffuse to the cytosol.
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Solubilization, purification, and characterization of a truncated form of rat hepatic squalene synthetase.
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The metabolism of native and malondialdehyde-altered low density lipoproteins by human monocyte-macrophages.
TLDR
Studies of the binding of 125I-native-LDL at 4 degrees C and the effects of chloroquine, Ca2+ concentration, and reductive methylation on high-affinity 125I's degradation indicate that native- LDL is processed by the monocyte-macrophages via the classic LDL receptor pathway.
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Structure and regulation of mammalian squalene synthase.
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cDNA cloning and gene expression analysis of human myo-inositol 1-phosphate synthase.
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Androgens stimulate coordinated lipogenic gene expression in normal target tissues in vivo
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Hepatic farnesyl diphosphate synthase expression is suppressed by polyunsaturated fatty acids.
TLDR
PUFA can down-regulate hepatic cholesterol synthesis through inhibition of HMG-CoA reductase and FPP synthase, at least in part through impairment of the SREBP pathway.
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