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koumine

National Institutes of Health

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Indole Alkaloids

Papers overview

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2019
2019
Induction of oxidative stress, apoptosis and DNA damage by koumine in Tetrahymena thermophila
Koumine is a component of the Chinese medicinal herb Gelsemium elegans and is toxic to vertebrates. We used the ciliate… 
2017
2017
Structural elucidation of koumine metabolites by accurate mass measurements using high-performance liquid chromatography/quadrupole-time-of-flight mass spectrometry.
RATIONALE Koumine is one of the major components of total alkaloids from Gelsemium. Koumine possesses a variety of interesting… 
2013
2013
Development of a sensitive and rapid UPLC-MS/MS method for the determination of koumine in rat plasma: application to a pharmacokinetic study.
A rapid, selective and sensitive method using UPLC-MS/MS was first developed and validated for quantitative analysis of koumine… 
2013
2013
Four new koumine metabolites in rat liver microsomes
Four new metabolites M-1 [1,2,18,19-tetradehydro-4-demethyl-3,17-epoxy-7,20(2H,19H)-cyclovobasan], M-2 [1,2,4,21,18,19… 
2013
2013
Two New Koumine-Type Indole Alkaloids from Gelsemium elegans Benth.
Two new indole alkaloids, 21-oxokoumine (1) and furanokoumine (2), were isolated from the roots of Gelsemium elegans Benth… 
2009
2009
[Antineoplastic effect of koumine in mice bearing H22 solid tumor].
OBJECTIVE To investigate the antitumor effects of koumine in mice bearing H22 solid tumor and its effect on the immune system of… 
2005
2005
[Therapeutic effects of koumine on psoriasis: an experimental study in mice].
OBJECTIVE To study the therapeutic effects of koumine on psoriasis in mouse models. METHODS The effects of koumine on… 
1998
1998
A chemical study on“Yakatsu (_??__??_)”stored in Shosoin repository
On the occasion of the second scientific investigation on ancient medicines stored in Shosoin repository, a chemical study of the… 
Review
1997
Review
1997
Chapter 1 Gelsemium Alkaloids
1982
1982
A Plausible Biogenetic Proposal for Koumine
The very recent structure determination [1] of the alkaloid koumine 1 [2—4] has prompted us to propose a likely biosynFig. 2… 
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